Multiple Sclerosis (MS) Support Group

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Dr loftus(need info)

deleted_user
deleted_user
i just moved to houston,tx. went to see Dr Loftus yesterday, seems to good to be true. does anybody know this doctor. i'm from ill and kinda scared to start with a new doctor when i have no one to refer me that i know. need some input on this doctor. he wants to start me on tsybari immediately. i've tried all the abc drugs and i just cant tolerate them, well copaxone i could but could not get used to shots everyday and the endents in my thighs. so i stopped. he also is testing me for devics disease instead of m.s. because of his evaluation. any input on this disease? i have had m.s. for 6 yrs why now think its something else.
LarryLDN
LarryLDN
Yep, Tysabri is the next step to offer in their wonderful new handbook.
deleted_user
deleted_user
I googled it it says its kinda like The main symptoms of Devic's disease are loss of vision and spinal cord function. As for other etiologies of optic neuritis,the visual impairment usually manifests as decreased visual acuity, although visual field defects, or loss of color vision may occur in isolation or prior to formal loss of acuity. Spinal cord dysfunction can lead to muscle weakness, reduced sensation, or loss of bladder and bowel control.[4] The typical patient has an acute and severe spastic weakness of the legs (paraparesis) or all four limbs (tetraparesis) with sensory signs, often accompanied by loss of bladder] control.


[edit] Mechanism
Devic's disease is similar to MS in that the body's immune system attacks the myelin surrounding nerve cells. Unlike standard MS, the attacks are not believed to be mediated by the immune system's T cells but rather by antibodies called NMO-IgG. These antibodies target a protein called aquaporin 4 in the cell membranes of astrocytes which acts as a channel for the transport of water across the cell membrane. [2] Aquaporin 4 is found in the processes of the astrocytes that surround the blood-brain barrier, a system responsible for preventing substances in the blood from crossing into the brain. The blood-brain barrier is weakened in Devic's disease, but it is currently unknown how the NMO-IgG immune response leads to demyelination.

Most research into the pathology of Devic's disease has focused on the spinal cord. The damage in the spinal cord can range from inflammatory demyelination to necrotic damage of the white and grey matter. The inflammatory lesions in Devic's disease have been classified as type II lesions (complement mediated demyelinization), but they differ from MS pattern II lesions in their prominent perivascular distribution. Therefore, the pattern of inflammation is often quite distinct from that seen in MS. [2][5]


[edit] Diagnosis
ms
TexasMS
TexasMS
I see Dr Rivera at the Maxine Messenger MS Clinic In Houston, but I do not know Dr. Loftus, sorry
deleted_user
deleted_user
what do you mean by that statement, LarryLDN?
LarryLDN
LarryLDN
Well, before Tysabri, once they ran you through the CRABs, they had nothing else to offer! Now they got Tysabri.
deleted_user
deleted_user
what are your thoughts on this drug?
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