Yes you do but they might be in his spine. I have them in brain & spine.

hi kelly does that mean if they in the spine a m.r.i wont pick them up then??? he had a m.r.i on his spine and it showed nothing thanks love lizxxx

If the MRI was done with & without contrast, it would show up.

i dont know about the contrast thing at alot our scanners in the uk are quite old and there are some scanners that show more detail so i dont know i cant find any info about mris at all but thanks so much for your help it may be he got something else and not m.s which would be a good thing as long as it wasnt another illness that was real bad thanks again love lizxxx

Hi Liz! I'm no where close to being a Doctor, but just wanted to add my 2 cents worth. I too have been showing signs of MS for awhile now, but my MRI's were also negative for lesions, both brain & spinal...although my spinal did have a shadow on it, thought to be artifactual (false positive) at this time, however, they want to re-scan me in 3-4 more months. My neuro. won't say whether she thinks MS or otherwise at this point. She did say that she thinks I definately have an autoimmune disease, other than just Fibromyalgia though.

I found an interesting article recently than your brother may want to read on some recent research studies regarding PPMS (one of the 4 categories of MS), stating that lesions aren't necessarely a requirement for the diagnosis for PPMS. It's an interesting read, to say the least. Here is the link:
http://www.msaa.com/articles/Primary_Progressive_MS_Update.htm
Enjoy! ;) ~Tonya

thanks so much tonja you sound so much like my brother all the symptons and yer the m.r.i s are clear he had had 3 in 2 years and still nothing that web site you gave was brill thanks so much it all sounded right cos he never well which is a sigh of pp m.s and yet it dont show on scans thanks so much for all the info love lizxxxx

In all the research I have done and listening to what my doctor has told me. i see an MS specialist. Some people are diagnosed without lesions..It is very hard and sometimes will take years but there are a few out there that have MS with no visible lesions as of yet...They have to be a certain size to show up on an MRI with or without contrast.. If all the physical, symptoms and Posotive LP are there. It is a possiblity...

hi there nay75az thanks so much for the info i found it interesting they make out mri shows everything but like you pointed out the small ones wont show my brov had a positive lp and all his neuro exams point to m.s he even on m.s meds which help to me its ovious he got m.s thanks so much loads of love lizxxx