I have been on plaquenil for one month, and am still waiting for the benefits to kick in. The biggest problem I had in the beginning was stomach upset. I was taking two pills in the AM, and started having stomach pain, so my rheumie changed me to taking one pill in the AM and one in the PM. I also make sure I take it on a FULL stomach, not just with a glass of milk that is recommended. Just remmember they say it can take a couple months to get full benefits. Good luck to you.

Stay on it for at least 3 month's, it doesn't give me pain relief, but it makes me healthier. Since being on it , (1pill a day) I no longer get colds and allergy attacks liike I used to, it also took away the inflammation in my liver. It is a malaria drug and is slow acting, (it takes years to be cured of malaria),but can stop malaria from ever being caught, when given as a preventative, so it will make you healthier and stronger in the long run.
I don't think it helps with pain, but I have Fibromyalgia too, so everything hurts anyhow..but it does keep me healthier, like an insurance policy, especially if you take any immuno-compromising medications like prednisone, methotrexate, cellcept ect..

Ive been on Plaquenil for almost 8 months and I have had NO side effects. I heard its one of the only ones that has hardly any side effects. If you can stay on it, do it. Try not to take the others. Im kind of in the middle right now because my dr wants to take me off plaquenil and put me on another. I dont wanna do that.

I have been on plaquenil for about 10yrs. It works great for me. It keeps my Lupus from flaring up and my hair from falling out. I think it is a great medication.

I used plaquenil for about a year and it had NO EFFECT except to make my vision blurry. Apparently it leaves some sort of deposits in your eyes. I quit taking it cuz it just wasn't doing anything for me.