I began taking LDN 1.5 mg then advanced to 4.5 mg. I went off Avonex at the same time. The improvement in my walking ability, depression and fatigue was absolutely wonderful. It may have been the combination that did it, or just getting on the LDN, but whatever, it worked. I recommend LDN to anyone with MS and understand it helps with other diseases also. I would like to hear back from some of you and your experiences with LDN.