COme on my friends please give some experience strength and hope here

The Topomax is of concern. There is precaution to be taken in anyone with renal insufficiency. You will need to have your urine monitored for BUN/creatinine every 3 mos just to be safe. This drug poses risk for nephrotoxicity and in someone with impaired kidney function, the risk is obviously greater. You'll probably have to come down to half dose or else be switched to another anticonvulsant such as Lamictal.

All drugs have the capacity of causing renal problems as that's the route most of them are excreted. Anybody taking any drugs should have blood work done once a year as part of a physical or more often if the drug is a known renal toxic compound. Only by looking at the lab values can you determine your level of renal insufficiency. You might not have to change your drugs if the benefits outweigh a mild case of renal insufficiency. For example I have a white blood cell count of 2.4 when the usual is 4.8 to 10.8, however I'm asymptomatic so don't need to have my meds changed.

Kidney failure or complications come from Lithium intake. A few other drugs will damage your kidneys, too. She never mentioned what drugs she's on!
Drugs like Tegretol will mimic lithium and you won't have to go for blood work.
Gapapentin is another one.
Change your meds, if it's affecting your kidneys/liver.

I take lots of them topomax, invega, clonazepam and zoloft. I know the topomax could be the culprit but I do not know about the rest.