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Tizanidine (Zanaflex) is a centrally acting a2-adrenergic agonist. It is used to treat the spasms, cramping, and tightness of muscles caused by medical problems such as multiple sclerosis, back pain, or certain injuries to the spine. more at Wikipedia

Treatment Success Rate

Top 5 Communities
Condition Members Success
Multiple Sclerosis (MS)
Chronic Pain
Back Pain
Migraine Headaches
Overall, 83% (1177 Members) find Zanaflex helpful

Zanaflex Reviews

Show: for
Working / Worked
This is great to relax muscles and help me sleep but doesnt last long so I take at bedtime annd then another if I wake up in the night.
Working / Worked
Working / Worked
Working / Worked
works well on tight muscles
It works somewhat for the spasms.
Working / Worked
Works great, but it is sedating for me so dosing is difficult at certain times of the day.
Working / Worked
On this muscle relaxer now and does seem to help some
Working / Worked
SO much better then flexeril!
Working / Worked
Had to stop when I started Aubagio.
Working / Worked
Currently taking 8 mg, 4 times a day for muscle rigidity.Works for me, but the effects are very short lasting.
Showing 1 - 10 of 1165 Reviews
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  1. Discussion: Zanaflex
    Zanaflex is not an opiate. It is used to "relax" your muscles, and hopefully, the pain that may be caused by tensed muscles. I have degene... [More]
  2. Discussion: Zanaflex
    I had an Appt. today with the neurosurgeon,They want me to start taking something called Zanaflex? I looked this one up and I don't want to be doing t... [More]
  3. Discussion: Zanaflex
    Glad to hear that it works for you. I take Zanaflex as well and have found it to have the least side effects compared to other muscle relaxers. The... [More]
  4. Discussion: Zanaflex
    Yeah, and yes I took Zanaflex for many, many years. It was the only muscle relaxant that worked for me without side effects. The dose can really var... [More]
  5. Discussion: Zanaflex
    I have been recently having horrific back and leg spasms and had my Pain doc appointment yesterday. He prescribed Zanaflex to go along with my pain m... [More]