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Tizanidine (Zanaflex) is a centrally acting a2-adrenergic agonist. It is used to treat the spasms, cramping, and tightness of muscles caused by medical problems such as multiple sclerosis, back pain, or certain injuries to the spine. more at Wikipedia

Treatment Success Rate

Top 5 Communities
Condition Members Success
Multiple Sclerosis (MS)
Chronic Pain
Back Pain
Migraine Headaches
Overall, 83% (1157 Members) find Zanaflex helpful

Zanaflex Reviews

Show: for
Working / Worked
SO much better then flexeril!
Working / Worked
Had to stop when I started Aubagio.
Working / Worked
Currently taking 8 mg, 4 times a day for muscle rigidity.Works for me, but the effects are very short lasting.
Working / Worked
Works very well for tight muscles, and also for sleep onset. I find this is a depressant, so I do not use often.
Working / Worked
I don't know
Working / Worked
Tizanadine for muscle pain. It is quite important and my goto choice for headaches lately.
Working / Worked
I need this to sleep!!! I also use it when I am having a difficult day.
to drowsy quit
Working / Worked
Works well
Working / Worked
don't remember
Showing 1 - 10 of 1147 Reviews
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  1. Discussion: Zanaflex
    Zanaflex is not an opiate. It is used to "relax" your muscles, and hopefully, the pain that may be caused by tensed muscles. I have degene... [More]
  2. Discussion: Zanaflex
    I had an Appt. today with the neurosurgeon,They want me to start taking something called Zanaflex? I looked this one up and I don't want to be doing t... [More]
  3. Discussion: Zanaflex
    Glad to hear that it works for you. I take Zanaflex as well and have found it to have the least side effects compared to other muscle relaxers. The... [More]
  4. Discussion: Zanaflex
    Yeah, and yes I took Zanaflex for many, many years. It was the only muscle relaxant that worked for me without side effects. The dose can really var... [More]
  5. Discussion: Zanaflex
    I have been recently having horrific back and leg spasms and had my Pain doc appointment yesterday. He prescribed Zanaflex to go along with my pain m... [More]