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What you should know before using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatrics

Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of pramlintide in children with use in other age groups.

Geriatric

This medicine has been tested and has not been shown to cause different side effects or problems in older people than it does in younger adults. However, some elderly people may be especially sensitive to the effects of low blood sugar. The doctor should manage pramlintide and insulin treatment to prevent an increased risk of severely low blood sugar.

Pregnancy CategoryExplanation
All TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Gastroparesis (a condition where the stomach takes too long to empty its contents) or
  • HbA1c9% (lab test that shows too high or low amount of sugar in the blood) or
  • Hypoglycemia unawareness (unable to recognize symptoms of low blood sugar until it becomes severe) or
  • Severe hypoglycemia (severe low blood sugar that comes back and has required assistance from medical personnel in the past 6 months)—If you have any of these conditions, you should NOT take pramlintide.
  • Hypoglycemia, insulin-induced, history of (low blood sugar brought on by using insulin in the past)—May increase risk of severe hypoglycemia occurring again