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S-adenosyl methionine (SAM) is a cofactor involved in methyl group transfers. In the United States SAM is sold as a nutritional supplement under the marketing name SAM-e (also spelled SAME or SAMe; pronounced "sam ee"). Some research has shown that taking SAM on a regular basis can help fight depression, liver disease,... more at Wikipedia

Treatment Success Rate

Top 5 Communities
Condition Members Success
Depression
17
88%
Cirrhosis
10
90%
Anxiety
5
80%
Bipolar Disorder
5
100%
Chronic Fatigue Syndrome
2
100%
Overall, 92% (50 Members) find SAM-e helpful
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SAM-e Reviews

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Working / Worked
natural medicine its a normally occuring chemical in the body that is EXCELLENT for treating depression. i have more energy although i feel low sometimes i no longer feel overwhelmed with all that i have to face
Working / Worked
When Ive been consistanly taking it its great but its so hard to remember to take it.
Working / Worked
No side effects and I guess it is doing it's job.
Working / Worked
It works in a psico level, no ansiety, etc..
Low transaminases in my case
Working / Worked
Unsure
Working / Worked
There was much improvement with this, it seemed to speed up the process of detoxification once my husband stopped drinking. Unfortunately he stopped taking it in his "denial" phase, but has started once again.
Working / Worked
I use SAM-e now. I like that it's a natural supplement.
Working / Worked
I use SAM-e now. I like that it's a natural supplement.
Working / Worked
I take the maximum dosage per day 1200 mgs in 3 doses of 400 mgs each and I can certainly tell the difference with I have missed a dose so although it doesnt get rid of the pain it certainly helps reduce it.
Working / Worked
At first, it worsened my anxiety. I cut my does in half and now at 200mg, I feel better
Showing 1 - 10 of 53 Reviews
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Discussions

  1. Discussion: Sam-E
    I took Sam E and it worked but then I discovered 5 HTTP and that seems to work too and I think it is cheaper and 5 HTTP seems to work better. [More]
  2. Discussion: Sam-E
    Sam-E tends to be unreliable for the mood boost, or tends to have fast poop out. [More]
  3. Discussion: SAM-e
    Here's info on SAM-e http://dietarysupplements.nlm.nih.gov/dietary/detail.jsp?fulltext=SAM-e&contain=14007106&name=Nature+Made+SAMe+Mood+Pl... [More]
  4. Advice: Sam-e
    Does Sam-e help/have an effect on someone in very early stage alzheimer's? Thanks. [More]
  5. Discussion: SAM-e
    my sister in law swears by sam-e. i haven't tried it. [More]

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