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Methotrexate, abbreviated MTX and formerly known as amethopterin, is an antimetabolite drug used in treatment of cancer and autoimmune diseases. It acts by inhibiting the metabolism of folic acid. more at Wikipedia

Treatment Success Rate

Top 5 Communities
Condition Members Success
Rheumatoid Arthritis
665
81%
Lupus
240
70%
Psoriasis
138
82%
Arthritis
96
88%
Crohn's Disease & Ulcer...
91
57%
Overall, 79% (1463 Members) find Methotrexate helpful
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Methotrexate Reviews

Show: for
Working / Worked
Works but takes a long time before it goes into effect.
Working / Worked
Hair Loss
Working / Worked
The maximum dose still wasn't enough.
Working / Worked
HATED I!!! The fatigue of RA is bad enough, throw the metho in the mix and the day or two of not feeling well. Nope, not for me.
Working / Worked
I had an initial flare up and was diagnosed with Psoriatic Arthritis ten years ago, so I started this med. and took it, along with birth control and folic acid (shouldn't get pregnant on it). It didn't help very much but it was at the beginning of my treatment so I didn't know that there were other options.
Improved lab work;nausea and migraine two full days after taking orally
Working / Worked
i'm on 20 mg injections right now. i switched to pills but the injection is more effective. i'm experiencing hair loss and a pinching sensation in the body
Working / Worked
working, but I take 6 2.5mg on friday night and am tired until Tuesday! Like sleep 40 hours at a time.
Working / Worked
It did help, but did not stop the progression
Working / Worked
Took on Sat. so I could throw up on Sunday so I could work on Monday
liver said no
Showing 41 - 50 of 1610 Reviews
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Discussions

  1. Discussion: methotrexate
    I've been on methotrexate for about 6 months now with the only side effect being a little fatigue. It doesn't help me much on its own, but does in co... [More]
  2. Discussion: Methotrexate
    I never took the methotrexate either ,One time I was so fed up with the preedisone I decide to take my self off big mistake I got real sick Fever ch... [More]
  3. Discussion: Methotrexate
    Hi, Renee I have been on methotrexate for almost 2 years now. I was very sick when I was taking the pill form. I had terrible headaches, diahrea, s... [More]
  4. Discussion: Methotrexate
    I HAVE NEVER TAKEN METHOTREXATE MYSELF, BUT I KNOW COMING OFF OF PREDNISONE TOO FAST CAN CAUSE YOU TO FEEL SICK, HAVE JOINT PAIN/ACHES. I KNOW MY DOCT... [More]
  5. Discussion: Methotrexate
    Hi I take methotrexate too. A couple words of wisdom. I was told to take it on a day when I don't have to go anywhere or do anything so that if the M ... [More]

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