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Methotrexate, abbreviated MTX and formerly known as amethopterin, is an antimetabolite drug used in treatment of cancer and autoimmune diseases. It acts by inhibiting the metabolism of folic acid. more at Wikipedia

Treatment Success Rate

Top 5 Communities
Condition Members Success
Rheumatoid Arthritis
Crohn's Disease & Ulcer...
Overall, 79% (2938 Members) find Methotrexate helpful

Methotrexate Reviews

Show: for
Working / Worked
Worked along with plaquinelle and folic acid for more than a year then FLARE up now must use strong pks as side affects
Working / Worked
Of all meds so far, seems to work the best. does cause some nausea and fatigue for a day after.
Working / Worked
7 years very well influenced by 15mg per week without problems very good mobility indicators in the norm. Stop activation process without methotrexate exactly two years.
Working / Worked
0.6 ml injection. Minimal side effects including fatigue the day after injection
Working / Worked
Worked great with prednisone, not so great alone
I dont know if its working. Doesnt feel like it
Working / Worked
Nov. 15, 2014 started taking three 2.5 mg (7.5 mg) once a week.
Jan. 14, 2015 started taking six 2.5 mg (15.0 mg) once a week.
Feb.11, 2015 started taking eight 2.5 mg.(20 mg.) tablets once a week.
Presently on 20 mg. of methotrexate once a week.
Working / Worked
Methotrexate is working for me, but my side effects include stomach upset. I also have a lot of bacterial infections due to the drug.
Working / Worked
Lab work is great, symptoms are so-so
Working / Worked
Only been on it for 2 weeks (4 tablets a week), have had a few waves of nausea, not sure if it is due to this or the Coxflam
Showing 1 - 10 of 3444 Reviews
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  1. Discussion: Methotrexate
    Hi! I am concerned about starting methotrexate therapy due to the fact that I am a nurse case manager for two different hospitals and I know tha... [More]
  2. Discussion: Methotrexate
    Has anyone experienced night sweats with methotrexate? [More]
  3. Discussion: methotrexate
    My rheum wants me to consider methotrexate. I wanted to hear from anyone who has taken this medication. How has it affected you good or bad. [More]
  4. Discussion: Methotrexate
    I've used methotrexate for four years now and I still have all my hair :-) I take mine on Sunday evenings (8 tablets now) and I do feel awful the nex... [More]
  5. Discussion: Methotrexate
    Hi All, Does anyone have experience with Methotrexate? Especially with Diamox?? I am to start it once a week today or tomorrow and wondering what... [More]