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Methotrexate, abbreviated MTX and formerly known as amethopterin, is an antimetabolite drug used in treatment of cancer and autoimmune diseases. It acts by inhibiting the metabolism of folic acid. more at Wikipedia

Treatment Success Rate

Top 5 Communities
Condition Members Success
Rheumatoid Arthritis
Crohn's Disease & Ulcer...
Overall, 79% (2979 Members) find Methotrexate helpful

Methotrexate Reviews

Show: for
Working / Worked
Currently on injections. Helping so far I notice a difference when I miss a dose.
It worked but I was sick all the time
No major side effects. Took it intravenously as well as intrathecally.
Working / Worked
Lethargic, it seems to be working.
Working / Worked
Worked from the beginning
It was part of my husband's chemo regimen. Feet and legs purpled, but have returned to my normal color with the exception of where the cellulitis was so bad.
Working / Worked
mouth sores as a side effect but otherwise pleased
Working / Worked
have not been on this one too long so not sure of benefits yet
Currently taking
Working / Worked
I believe this helped, but 1) caused blisters on my hands and 2) caused liver problems. Still taking, but at reduced dosage, and my large joints (hips, shoulders, knees) are killing me.
Showing 1 - 10 of 3490 Reviews
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  1. Discussion: Methotrexate
    Hi! I am concerned about starting methotrexate therapy due to the fact that I am a nurse case manager for two different hospitals and I know tha... [More]
  2. Discussion: Methotrexate
    Has anyone experienced night sweats with methotrexate? [More]
  3. Discussion: methotrexate
    My rheum wants me to consider methotrexate. I wanted to hear from anyone who has taken this medication. How has it affected you good or bad. [More]
  4. Discussion: Methotrexate
    I've used methotrexate for four years now and I still have all my hair :-) I take mine on Sunday evenings (8 tablets now) and I do feel awful the nex... [More]
  5. Discussion: Methotrexate
    Hi All, Does anyone have experience with Methotrexate? Especially with Diamox?? I am to start it once a week today or tomorrow and wondering what... [More]