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Methotrexate, abbreviated MTX and formerly known as amethopterin, is an antimetabolite drug used in treatment of cancer and autoimmune diseases. It acts by inhibiting the metabolism of folic acid. more at Wikipedia

Treatment Success Rate

Top 5 Communities
Condition Members Success
Rheumatoid Arthritis
Crohn's Disease & Ulcer...
Overall, 79% (2969 Members) find Methotrexate helpful

Methotrexate Reviews

Show: for
Working / Worked
Worked from the beginning
It was part of my husband's chemo regimen. Feet and legs purpled, but have returned to my normal color with the exception of where the cellulitis was so bad.
Working / Worked
This has helped my lungs. I was able to breath normal and not gasp for breath. I took this for a period of 6 months and I would take it again despite the side effects which were minimal for me.
Working / Worked
mouth sores as a side effect but otherwise pleased
Working / Worked
have not been on this one too long so not sure of benefits yet
Currently taking
Working / Worked
I believe this helped, but 1) caused blisters on my hands and 2) caused liver problems. Still taking, but at reduced dosage, and my large joints (hips, shoulders, knees) are killing me.
Working / Worked
i Hate it. Took it for so long that I started to manifset nausea and dizziness at the sight of the shot.
poisoned me.
Working / Worked
I have been on metho for 3 years. I take 7 every week, never had a problem with this drug.
Showing 1 - 10 of 3480 Reviews
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  1. Discussion: Methotrexate
    Hi! I am concerned about starting methotrexate therapy due to the fact that I am a nurse case manager for two different hospitals and I know tha... [More]
  2. Discussion: Methotrexate
    Has anyone experienced night sweats with methotrexate? [More]
  3. Discussion: methotrexate
    My rheum wants me to consider methotrexate. I wanted to hear from anyone who has taken this medication. How has it affected you good or bad. [More]
  4. Discussion: Methotrexate
    I've used methotrexate for four years now and I still have all my hair :-) I take mine on Sunday evenings (8 tablets now) and I do feel awful the nex... [More]
  5. Discussion: Methotrexate
    Hi All, Does anyone have experience with Methotrexate? Especially with Diamox?? I am to start it once a week today or tomorrow and wondering what... [More]