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Methotrexate, abbreviated MTX and formerly known as amethopterin, is an antimetabolite drug used in treatment of cancer and autoimmune diseases. It acts by inhibiting the metabolism of folic acid. more at Wikipedia

Treatment Success Rate

Top 5 Communities
Condition Members Success
Rheumatoid Arthritis
Crohn's Disease & Ulcer...
Overall, 79% (3052 Members) find Methotrexate helpful

Methotrexate Reviews

Show: for
Working / Worked
Worked great for first couple of years, I fear it's working less and less, increasing dose
Working / Worked
was on methotrexate for two years with no effect. Now not on any prescription meds.
Working / Worked
Worked for one year. Liver levels went up and my doctor took me off the meds. I cried that day.
Working / Worked
think it has stopped working
Working / Worked
Working okay
Working / Worked
Discontinued when my liver went bonkers.
Was the only thing that worked for me 20+ years ago. Went as high as 25 mg. Now take 7.5 mg with Humira
Working / Worked
Have no clue if it works. Been on it for 10 years and my rheumy says it helps with inflammation and to continue taking.
Working / Worked
did fine but can't take it any more
Working / Worked
Been on for long time. Made mistake of going off all meds bc I felt so much better...BIG mistake. Been back on 3 months with some improvement still waiting for it to work like before, was also on Leflunomide previously but RA Dr. wants to try with only one immune suppressant, jury still out!
Showing 1 - 10 of 3577 Reviews
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  1. Discussion: Methotrexate
    My rheumatologist automatically put me on folic acid when I was put on methotrexate. [More]
  2. Discussion: Methotrexate
    Hi! I am concerned about starting methotrexate therapy due to the fact that I am a nurse case manager for two different hospitals and I know tha... [More]
  3. Discussion: Methotrexate
    Has anyone experienced night sweats with methotrexate? [More]
  4. Discussion: methotrexate
    My rheum wants me to consider methotrexate. I wanted to hear from anyone who has taken this medication. How has it affected you good or bad. [More]
  5. Discussion: Methotrexate
    Hi All, Does anyone have experience with Methotrexate? Especially with Diamox?? I am to start it once a week today or tomorrow and wondering what... [More]