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Methotrexate, abbreviated MTX and formerly known as amethopterin, is an antimetabolite drug used in treatment of cancer and autoimmune diseases. It acts by inhibiting the metabolism of folic acid. more at Wikipedia

Treatment Success Rate

Top 5 Communities
Condition Members Success
Rheumatoid Arthritis
Crohn's Disease & Ulcer...
Overall, 79% (2855 Members) find Methotrexate helpful

Methotrexate Reviews

Show: for
No known side effects from this yet. It is intrathecal, and he had a headache from that once.
Working / Worked
Worked but just had to start injections to get more into my system.
Working / Worked
Just started it. So far it makes me really tired the day I take it.
Working / Worked
This is another drug that I was on for about 10 years. Not sure if it was working or not. Thankfully I was taken off it to start another drug. This is a chemo drug so I'm glad I'm not taking it anymore. I did not have any side effects.
Working / Worked
Was taken off
Working / Worked
Worked great until I began having major side effects of losing 1/2 of my hair. Wish I could still take this.
Working / Worked
wound up with End stage liver disease cirrhosis :(
This does help, but isn't strong enough for me alone. Side effects are fatigue at high doses, and ulcer on my tongue and gums.
Working / Worked
just started so no comments yet
Working / Worked
I am feeling somewhat better.
Showing 1 - 10 of 3347 Reviews
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  1. Discussion: Methotrexate
    Has anyone experienced night sweats with methotrexate? [More]
  2. Discussion: methotrexate
    My rheum wants me to consider methotrexate. I wanted to hear from anyone who has taken this medication. How has it affected you good or bad. [More]
  3. Discussion: Methotrexate
    I've used methotrexate for four years now and I still have all my hair :-) I take mine on Sunday evenings (8 tablets now) and I do feel awful the nex... [More]
  4. Discussion: Methotrexate
    Hi All, Does anyone have experience with Methotrexate? Especially with Diamox?? I am to start it once a week today or tomorrow and wondering what... [More]
  5. Discussion: Methotrexate
    Taking methotrexate for 2 months. I am now up to the max dosage of 20 mg that my doctor prescribed. The only side effect so far are mouth sores but a ... [More]