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Methotrexate, abbreviated MTX and formerly known as amethopterin, is an antimetabolite drug used in treatment of cancer and autoimmune diseases. It acts by inhibiting the metabolism of folic acid. more at Wikipedia

Treatment Success Rate

Top 5 Communities
Condition Members Success
Rheumatoid Arthritis
Crohn's Disease & Ulcer...
Overall, 79% (2924 Members) find Methotrexate helpful

Methotrexate Reviews

Show: for
I dont know if its working. Doesnt feel like it
Working / Worked
Nov. 15, 2014 started taking three 2.5 mg (7.5 mg) once a week.
Jan. 14, 2015 started taking six 2.5 mg (15.0 mg) once a week.
Feb.11, 2015 started taking eight 2.5 mg.(20 mg.) tablets once a week.
Presently on 20 mg. of methotrexate once a week.
Working / Worked
Methotrexate is working for me, but my side effects include stomach upset. I also have a lot of bacterial infections due to the drug.
Working / Worked
Lab work is great, symptoms are so-so
Working / Worked
Only been on it for 2 weeks (4 tablets a week), have had a few waves of nausea, not sure if it is due to this or the Coxflam
Working / Worked
Guess I will be forever on this drug
Working / Worked
currently on
Working / Worked
still taking this med unsure of any benefit
Working / Worked
affected his liver and kidney levels
Makes the RA better, but the side effects are horrible. Nausea and headaches...ugh!
Showing 1 - 10 of 3424 Reviews
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  1. Discussion: Methotrexate
    Hi! I am concerned about starting methotrexate therapy due to the fact that I am a nurse case manager for two different hospitals and I know tha... [More]
  2. Discussion: Methotrexate
    Has anyone experienced night sweats with methotrexate? [More]
  3. Discussion: methotrexate
    My rheum wants me to consider methotrexate. I wanted to hear from anyone who has taken this medication. How has it affected you good or bad. [More]
  4. Discussion: Methotrexate
    I've used methotrexate for four years now and I still have all my hair :-) I take mine on Sunday evenings (8 tablets now) and I do feel awful the nex... [More]
  5. Discussion: Methotrexate
    Hi All, Does anyone have experience with Methotrexate? Especially with Diamox?? I am to start it once a week today or tomorrow and wondering what... [More]