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(also known as Sinequan)

Topical doxepin is used to relieve itching in patients with certain types of eczema. It appears to work by preventing the effects of histamine, which is a substance produced by the body that causes itching.

Doxepin is available only with your doctor's prescription.

Common Brand Names:


Treatment Success Rate

Top 5 Communities
Condition Members Success
Bipolar Disorder
Overall, 80% (125 Members) find Doxepin helpful

Doxepin Reviews

Show: for
Working / Worked
prescribed for insomnia but I came to realize that it is also an antidepressant
Working / Worked
works right away
Working / Worked
Helps me sleep reduces pain.
Working / Worked
10 mg twice daily. Effective but still have symptoms and flares
Working / Worked
It didn't help me.
Working / Worked
It helps but it does not always works.
Working / Worked
Usually works well to help me sleep and feel better overall. Extra stress still wakes me often during the night.
Working / Worked
It used to work great. I quit taking it for a few years because of another health condition but I got back on it over a year ago 75 mg a day. It helps me sleep. It used to help with anxiety and maybe it still does but I dont feel at all sedated by it I used to.
Working / Worked
needed for me to sleep
Working / Worked
taken at night keeps my muscles for tightening involuntarily works but has made me gain weight
Showing 1 - 10 of 152 Reviews
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  1. Discussion: Do the drugs work??
    I've taken a cousin of Elavil for over 20 years, it's called Doxepin or Sinequan. I love it. I did walk into walls when I first started but my body ... [More]
  2. Discussion: Can doxepin work for OCD?
    TCAs are the older meds, for me they have far more anti anxiety effects at a physical level. At smaller doses some are used for pain and insomnia. ... [More]
  3. Discussion: Can doxepin work for OCD?
    For me, the SSRI's are the only answer. In combination with a anxiety drug it can work... but then the anxiety pills they can only prescribe for 10 d... [More]
  4. Discussion: Can doxepin work for OCD?
    Im having bad OCD at the mo. Normally my anxiety is GAD but sometimes I get OCD from events that remind me of bad events so I ruminate over and over t... [More]
  5. Discussion: Can I Be Honest about Despair?
    When I first got CFS, 20 years ago, my shrink whose husband had CFS told me to take the CFS "cocktail". It was klonopin and doxepin (Sinequ... [More]