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(also known as Sinequan)

Topical doxepin is used to relieve itching in patients with certain types of eczema. It appears to work by preventing the effects of histamine, which is a substance produced by the body that causes itching.

Doxepin is available only with your doctor's prescription.

Common Brand Names:


Treatment Success Rate

Top 5 Communities
Condition Members Success
Bipolar Disorder
Overall, 79% (121 Members) find Doxepin helpful

Doxepin Reviews

Show: for
Working / Worked
10 mg twice daily. Effective but still have symptoms and flares
Working / Worked
Felt a little better on it but Pdoc wants me to phase it out.
Working / Worked
It didn't help me.
Working / Worked
It helps but it does not always works.
Working / Worked
Usually works well to help me sleep and feel better overall. Extra stress still wakes me often during the night.
Working / Worked
It used to work great. I quit taking it for a few years because of another health condition but I got back on it over a year ago 75 mg a day. It helps me sleep. It used to help with anxiety and maybe it still does but I dont feel at all sedated by it I used to.
Working / Worked
needed for me to sleep
Working / Worked
taken at night keeps my muscles for tightening involuntarily works but has made me gain weight
Working / Worked
Take this is combination with my cymbalta
Working / Worked
Just too many side effects!
Showing 1 - 10 of 148 Reviews
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  1. Discussion: Can I Be Honest about Despair?
    When I first got CFS, 20 years ago, my shrink whose husband had CFS told me to take the CFS "cocktail". It was klonopin and doxepin (Sinequ... [More]
  2. Discussion: Do you take psych meds too?
    Yes. I take doxepin for the anxiety attacks. My thyroid is not yet optimal, so hopefully it gets better. But I needed something to help in the mean... [More]
  3. Discussion: My labs took a nosedive!
    Sovgrateful..... My anxiety is about 80% better on the doxepin. I do think, however, that the doxepin caused my thyroid labs to plummet. I defini... [More]
  4. Discussion: rashes
    I dont know if you also have itching as a side effect to the rashes but I take hydroxyzine and doxepin at night to relieve the itching [More]
  5. Discussion: New here
    I am on Lithium, Cymbalta, Tamazapam and doxepin for sleep, omega 3 fish oil and Lithium Orotate for an extra kick without the toxicity issues. This... [More]