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(also known as Norpramin, Pertofrane)
Desipramine is a tricyclic antidepressant (TCA) that inhibits the reuptake of norepinephrine. It is sold under the brand names Norpramin© and Pertofrane©. It is used to treat depression, but not considered a first line treatment since the introduction of SSRI antidepressants. more at Wikipedia

Treatment Success Rate

Top 5 Communities
Condition Members Success
Bipolar Disorder
Depression - Teen
Overall, 48% (406 Members) find Desipramine helpful

Desipramine Reviews

Show: for
Working / Worked
tried it but then got pregnant. dry mouth...
Working / Worked
It was helping for my depression, but I had an allergic reaction (developed a rash on my arms & chest), so I had to discontinue it.
Working / Worked
didn't work
Working / Worked
stopped working
Working / Worked
Not so sure..use it for restless leg syndrome. Take 25 mg.
Working / Worked
didn't seem to help- this was right after the baby, I think
Working / Worked
I am currently working with this drug. It seems to be working well and just needs some adjusting or some tuning.
Working / Worked
If Immipramine is in this category, then yes, this worked wonders before the prozac and other Serontonin agents were introduced to the FDA.
Working / Worked
worked pretty good with cymbalta to help with narcolepsy
Working / Worked
works but limited in mg since it made me clumsy and I fell in the street and broke my elbow- now on 100 and OK
Showing 1 - 10 of 362 Reviews
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  1. Discussion: What not to eat while taking Harvoni
    possibly pomegranate. [More]
  2. Discussion: any treatment for major depressive disorder?
    Don't give up. Most likely, there is a drug out there that will make your life not just bearable but even enjoyable. It took me many years to find the... [More]
  3. Discussion: how to get up in the morning
    While I still have issues waking up, I'm not nearly as bad as I was before I started taking Desipramine every night. All I need is 25-50mg a night (5... [More]
  4. Discussion: Trigeminal pain
    I was dx'd with atypical trigeminal neuralgia following questionable dental work. I just started a post/thread about it. The pain was and still is at ... [More]
  5. Advice: What effective medications can I take?
    I am on desipramine for depression and it doesnt have any real side effects., I have not gained any weight on it. The trazadone I have to sleep als... [More]