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(also known as Diphenhydramine hydrochloride)
Diphenhydramine hydrochloride (trade name Benadryl®, as produced by Pfizer or Dimedrol outside the US) is an over-the-counter (OTC) antihistamine and sedative. It is also given in conjunction with typical antipsychotics to prevent akathisia. It is a member of the ethanolamine class of antihistaminergic agents. more at Wikipedia

Treatment Success Rate

Top 5 Communities
Condition Members Success
Environmental Allergies
Food Allergies
Bipolar Disorder
Overall, 86% (362 Members) find Benadryl helpful

Benadryl Reviews

Show: for
Working / Worked
I use it when I need sleep once in a while
Working / Worked
Generic Benadryl is what I use (100mg) and it's definitely working.
as needed
Working / Worked
Benadryl helps best in the gel topical form.
Working / Worked
worked for a while on its own seems more like a short term fix.
Working / Worked
Working / Worked
This seems to start working for me in about a half hour, but it usually puts me to sleep as well.
Working / Worked
I experienced severe congestion and stuffiness. Benadryl dried up my sinuses but also made me a little sleepy.
Working / Worked
Worked for minor outbreak
Working / Worked
I take 3-4 then go to bed. It makes them go away for the night.
Showing 51 - 60 of 344 Reviews
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  1. Discussion: Benadryl
    Cheryl, that is hilarious! I am really sensitive to Benadryl. I take Zyrtec as a premed and then only use Benadryl if I get itching once I am star... [More]
  2. Discussion: Benadryl
    also for poison ivy, try the Benadryl Gel, that way it's right on the rash. I only ever had to take two benadryl like once in my life. I was cleani... [More]
  3. Discussion: Benadryl
    I have allergies like crazy. Took one benadryl 25mcgs and now feeling like going back to bed. Might just do that.LOL [More]
  4. Discussion: Benadryl
    Yes, hun. Please let us know if the benadryl helps the nerve pain. I have not heard it used for this either but I would be interested in seeing if i... [More]
  5. Discussion: Benadryl
    Does anyone know the main ingrediant in Benadryl that helps nerve pain, as there are a few different ones here in England. susie x [More]