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(also known as Diphenhydramine hydrochloride)
Diphenhydramine hydrochloride (trade name Benadryl®, as produced by Pfizer or Dimedrol outside the US) is an over-the-counter (OTC) antihistamine and sedative. It is also given in conjunction with typical antipsychotics to prevent akathisia. It is a member of the ethanolamine class of antihistaminergic agents. more at Wikipedia

Treatment Success Rate

Top 5 Communities
Condition Members Success
Environmental Allergies
Food Allergies
Bipolar Disorder
Overall, 86% (362 Members) find Benadryl helpful

Benadryl Reviews

Show: for
Working / Worked
25mg to 100 mg during the day will make me feel relaxed sometimes tired100mg to 200mg will make me fall asleep at nightside effect is intense dreams and dry mouthalso it is cheap 100 pills for 4.00
Helps me to fall asleep but make sure you take it so that you have at least 6-8 hours of sleep or else you will feel groggy (they call it a benadryl hangover).
Working / Worked
For the most part it settles my body down... no itches better breathing.
Working / Worked
I use it when I need sleep once in a while
Working / Worked
Generic Benadryl is what I use (100mg) and it's definitely working.
as needed
Working / Worked
Benadryl helps best in the gel topical form.
Working / Worked
worked for a while on its own seems more like a short term fix.
Working / Worked
Working / Worked
This seems to start working for me in about a half hour, but it usually puts me to sleep as well.
Showing 51 - 60 of 347 Reviews
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  1. Discussion: Benadryl
    Cheryl, that is hilarious! I am really sensitive to Benadryl. I take Zyrtec as a premed and then only use Benadryl if I get itching once I am star... [More]
  2. Discussion: Benadryl
    also for poison ivy, try the Benadryl Gel, that way it's right on the rash. I only ever had to take two benadryl like once in my life. I was cleani... [More]
  3. Discussion: Benadryl
    I have allergies like crazy. Took one benadryl 25mcgs and now feeling like going back to bed. Might just do that.LOL [More]
  4. Discussion: Benadryl
    Yes, hun. Please let us know if the benadryl helps the nerve pain. I have not heard it used for this either but I would be interested in seeing if i... [More]
  5. Discussion: Benadryl
    Does anyone know the main ingrediant in Benadryl that helps nerve pain, as there are a few different ones here in England. susie x [More]