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Common known side effects

In rats, spironolactone has been found to increase the risk of tumors. It is not known if spironolactone increases the chance of tumors in humans.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Rare
For amiloride, spironolactone, and triamterene
- Skin rash or itching- shortness of breath
For spironolactone and triamterene only (in addition to effects listed above)
- Cough or hoarseness- fever or chills- lower back or side pain- painful or difficult urination
For triamterene only (in addition to effects listed above)
- Black, tarry stools- blood in urine or stools- bright red tongue- burning, inflamed feeling in tongue- cracked corners of mouth- lower back pain (severe)- pinpoint red spots on skin- unusual bleeding or bruising- weakness
Signs and symptoms of too much potassium
- Confusion- irregular heartbeat- nervousness- numbness or tingling in hands, feet, or lips- shortness of breath or difficult breathing- unusual tiredness or weakness- weakness or heaviness of legs

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

less common with amiloride and triamterene

- Nausea and vomiting- stomach cramps and diarrhea
Less common
For amiloride, spironolactone, and triamterene
- Dizziness- headache
For amiloride and spironolactone only (in addition to effects listed above)
- Decreased sexual ability
For amiloride only (in addition to effects listed above)
- Constipation- muscle cramps
For spironolactone only (in addition to effects listed above for spironolactone)
- Breast tenderness in females- clumsiness- deepening of voice in females- enlargement of breasts in male- inability to have or keep an erection- increased hair growth in females- irregular menstrual periods- sweating
For triamterene only (in addition to effects listed above for triamterene)
- Increased sensitivity of skin to sunlight
Signs and symptoms of too little sodium
- Drowsiness- dryness of mouth- increased thirst- lack of energy

For male patients: Spironolactone sometimes causes enlarged breasts in males, especially when they take large doses of it for a long time. Breasts usually decrease in size gradually over several months after this medicine is stopped. If you have any questions about this, check with your doctor.

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.


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