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danettejett 
11:43pm, December 2, 2008
Hey you all I am just doing some research on why we seem to have such brain fog and or why our symptoms seem to have effects on our brain functioning - especially the hypothalamus. Our brains ofcourse are the center of our nervous system and we need them to signal all areas of our bodies (organs, hormones) to function right. What happens with CFS that causes our systems to malfunction? Could it be that our brains are being poisoned?
What is the blood brain barrier (BBB)? The BBB is there to protect high density cells restricting passages of foreign substances from the bloodvessels to the brain.
I was reading that viruses can bypass through the blood-brain barrier by attaching themselves to circulatory immune cells. (I have the EBV) Therefore it can reach our brains and do damage to certain areas.
The hypothalamus specifically the Subfornical Organ is outside of the blood-brain barrier so nuerons in this region can respond to factors that are present in the systemic circulation. The Subfornical Organ regulates fluid and electrolyte balance, thrist, soduim excretion, blood volume regulation, vasopression, osmotic pressure of blood. CFS patients have these symptoms.
Again, The Blood Brain Barrier is there to protect high density cells restricting passage of substances from the blood stream to the brain. The blood-brain barrier is composed of high density cells restricting passage of substances from the bloodstream much more than endothelial cells in capillaries elsewhere in the body. Astrocyte cell projections called astrocytic feet (also known as "glia limitans") surround the endothelial cells of the BBB, providing biochemical support to those cells. The BBB is distinct from the similar blood-cerebrospinal fluid barrier, a function of the choroidal cells of the choroid plexus, and from the Blood-retinal barrier, which can be considered a part of the whole[1]
What do you all think? Help me out here....
Posted on 11/13/08, 06:11 pm
What is the blood brain barrier (BBB)? The BBB is there to protect high density cells restricting passages of foreign substances from the bloodvessels to the brain.
I was reading that viruses can bypass through the blood-brain barrier by attaching themselves to circulatory immune cells. (I have the EBV) Therefore it can reach our brains and do damage to certain areas.
The hypothalamus specifically the Subfornical Organ is outside of the blood-brain barrier so nuerons in this region can respond to factors that are present in the systemic circulation. The Subfornical Organ regulates fluid and electrolyte balance, thrist, soduim excretion, blood volume regulation, vasopression, osmotic pressure of blood. CFS patients have these symptoms.
Again, The Blood Brain Barrier is there to protect high density cells restricting passage of substances from the blood stream to the brain. The blood-brain barrier is composed of high density cells restricting passage of substances from the bloodstream much more than endothelial cells in capillaries elsewhere in the body. Astrocyte cell projections called astrocytic feet (also known as "glia limitans") surround the endothelial cells of the BBB, providing biochemical support to those cells. The BBB is distinct from the similar blood-cerebrospinal fluid barrier, a function of the choroidal cells of the choroid plexus, and from the Blood-retinal barrier, which can be considered a part of the whole[1]
What do you all think? Help me out here....
Posted on 11/13/08, 06:11 pm
Comments
Articles I have read about over the past couple of years seem to support the view that ME is caused by a neurophilic virus that lives deep in the brain stem and damages critical systems that control the regulatory functions of the body through the HPA axis, etc. It would not show up in blood work if it does not normally maintain high levels in the circulatory system, residing instead primarily in neural tissues. After all, the virus that causes shingles, Varicella zoster, does not show up as a viral infection when blood work is done, even though everyone who has ever had chicken pox carries it in their bodies. It just lives in neural tissue as a permanent resident of the body, causing problems only when the immune system is compromised or the person is extremely stressed.
I have often thought to myself that ME may be originally a childhood disease like chicken pox, nothing distinctive about it, and transmitted among children. Then later on, when we are stressed by something it becomes ME, just like Varicella zoster becomes shingles.
RichieD
A friend of mine who also has chronic fatigue (she didn't have EBV though she became ill after a blood transfusion 4 years ago) She also lives in London Uk like me and she was part of a study where quite a few CFS patients had brain scans but she still doesn't know what the study showed. I hope she finds out as I would be very interested to know aswell as many others.
I think we can definately say that CFS is caused by a virus, your, mine and a majority was caused by the EBV.
I do think though that somehow this virus attacks the nervous system and this is why I have now been started on weekly vitamin B12 injections which helps the nervous system and aids healthy red blood cells.
It definatley affects the brain somehow though and I really think there should be a lot more research into this and hopefully one day they will come up with a cure to correct what has gone wrong in our bodies. I am forever hopeful though and truly believe that we will all get better again sometime.
babymoonlight79