The skeletal, or bone-specific, isoform of alkaline phosphatase is a tetrameric glycoprotein found on the surface of osteoblast cells. Osteoblast are a type of cell responsible for lying down the protein matrix of bone, which calcium salts (particularly phosphates) are deposited. The function of bone-specific alkaline phosphatase (BAP) is shown to be a biochemical indicator of bone turnover. BAP and Osteoblast cells work together to build NEW bone. Building NEW bone is the real answer to overcome Osteoporosis.
Bone health - Replenishments
Bone is living tissue that is continually being broken down and rebuilt. As we age bone breakdown begins to outweigh bone rebuilding, and certain life style adjustments can alter the rate at which this occurs. However, certain bone conditions that are triggered due to a disease condition or age are difficult to reverse. In most such cases, these bone conditions are adversely compounded by other underlying factors such as chemical imbalances, physiological deficiencies and/or disorders.Specific receptors for lactoferrin (LF) are present on immune cells including neutrophils, monocytes, lymphocytes and on tissues of liver, intestinal, urogenital and respiratory tracts. Interaction of LF with these receptors is essential for several
body functions such as hormone regulation, tissue repair, bone regeneration, blood detoxification and energy generation. Numerous functions have been reported and continue to be reported for LF, some of which are related to its iron-binding properties [Naidu and Bidlack, 1998]. LF plays a critical role in the intestinal absorption and physiological transport of several essential metals including iron, zinc, manganese, and selenium. The ability of LF to bind iron in the presence of bicarbonate anion contributes to antibacterial, antiviral, antifungal, anti-inflammatory, antioxidant and immuno-modulatory activities [Naidu and Arnold, 1997]. LF is a multifunctional replenishment highly critical for a bone health, in particular.
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