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  Hug

  From Bethann42 June 5

  Thank you so much ...it really helps to talk to people that know what your going through.
  
  Thanks again ,
  Beth

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  I’m With You

  From 64ford December 26, 2008

  University of California Davis Cancer Center researchers have come across a way to block a cancer gene’s own repair mechanism and make chemotherapy more effective for kidney cancer patients. The findings, considered the first of its kind, are published in the Cancer Biology and Therapy report. “Cancer cells are notorious in their ability to rapidly create copies of themselves,” said Robert Weiss, a UC Davis professor of nephrology and chief of nephrology at the Sacramento Veterans’ Affairs Hospital. “While the latest medications slow down that process, they do not tend to be curative and have many side effects. We wanted to find ways to help make chemotherapeutics as effective as possible at the lowest doses possible.” New chemotherapy medications destabilize cancer cells at the DNA level, reducing their ability to replicate, Weiss said in a news release. He was aware that the p21 gene has a critical role in restoring cancer cell DNA and possibly circumventing the benefits of those treatments, so Weiss focused on identifying compounds that could interrupt the pathway. The team tested thousands of compounds and determined that 12 bind to the recombinant protein p21. Three of the compounds decreased p21 expression, blocking kidney cancer cells’ ability to recover and increase their responsiveness to treatments. “The results are very exciting, especially given how difficult kidney cancer has so far been to treat,” Weiss said. “Our work offers hope that in the future these p21 inhibitors can be refined and used in concert with other conventional as well as novel cancer treatments to increase the comfort and life spans of patients with kidney cancer.” Now, Weiss and his team will focus on three candidate compounds to determine the lowest concentrations that will remain effective and to optimize their anti-cancer properties. He will test those compounds with standard treatments in animal models and, if successful, later in human trials. “The goal is to find new approaches to treating a cancer for which few options currently exist and make those approaches available in clinical settings as quickly as possible,” he said. Other authors in the study are See-Hyoung Park, Xiaobing Wang, Riuwi Liu and Kit Lam. The research was supported by the National Cancer Institute, U.S. Department of Veterans’ Affairs, Morris Animal Foundation, National Institutes of Health and National Science Foundation.

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  Rainbow

  From 64ford December 25, 2008

  Joy to you and yours on this blessed day. Rudy B cancer fighter. Doing well this day God has Bless us all....

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  Santa

  From joyciesgirl December 24, 2008

  Merry Christmas. Love Sherrie

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  Hug

  From joyciesgirl December 21, 2008

  Thanks for your note of support. Things are getting easier. Love Sherrie

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