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Dr. Shapiro completed his undergraduate education at UC San Diego, earning a B.S. in Biochemistry and Cell Biology, and a B.A. in Political Science. He furthered his education at UCLA where he earned a Masters Degree in Public…
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Acetaminophen and Asthma: Is There a Link?
Posted in Asthma by Dr. Jeremy F. Shapiro on Sep 19, 2008


A new study just published in the medical journal Lancet will be receiving a world-wide media blitz these next few days as it prompts concerns of a link between infantile use of paracetamol (known as acetaminophen in the U.S.) with an increased risk of developing asthma and eczema in children 6 to 7 years of age.    The researchers of this study analyzed data from over 200,000 children covering 31 countries and found nearly a 50% increased risk of asthma in those who were exposed to paracetamol as an infant when compared to infants who had never taken the medication.  Furthermore, other results found when paracetamol was used in the previous 12 months (but less than once a month), there followed a 61% greater risk of asthma.


Now what I find interesting is that in 2001, there was a large cross sectional study performed (including 140,000 participants from 22 countries worldwide) which was published in the European Respiratory Journal that described a link between paracetamol use with an increased risk of asthma.  Granted, no causal association was found.  But my question is why has there not been greater inquiry into this association over the past few years?


The authors of the current study do provide a possible theory as to why this occurrence exists (related to antioxidant levels in the body), but what needs to be done is more definitive studies to determine whether there is a causal association.


For now, until definitive research defines this causal association, I will continue to use acetaminophen selectively in my infants...with significant pain and/or high temperature.


 


Dr. Jeremy


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Forgive me for my ignorance on the topic, but it seems to me that perhaps people who experience allergic reactions and diseases like eczema and asthma may be more likely to take acetaminophen than those who do not, and that it why the association between the two exists. Perhaps parents with these conditions want to treat their children with acetaminophen because they believe it will reduce inflammation in their children and reduce unpleasant inflammatory symptoms. Eczema and asthma are hereditary, so it would make sense that a parent with these conditions who has found relief from acetaminophen would administer the medication to their children who are already susceptible to the condition.
By lightbright  Jul 16, 2010
3
Not sure, but couldn't this be one of those "People who wear skirts are over-represented in those with ovarian cancer." kind of things. So kids who are going to get asthma tend to get more chest infections as infants and require more doses of paracetamol than those who aren't. I agree that there need to be studies into a causal relationship.

And Rose, I gave my baby paracetamol too. If you don't know, though, you can't be defined as a bad parent.
By ClaresMom  Sep 23, 2008
2
Very good info. Thank you. Eddy123
By Eddy123  Sep 20, 2008
1
this would explain alot if they were linked together.
if linked I would be a bad mother;reason I give my kids infant and children's meds containing acetaminophen.
Rose
By SunflowerRose  Sep 20, 2008
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