Loved Ones who support someone with MS Community Group
This group is meant for those who help someone with MS. This would include family, good friends, spouses and caregivers. It is a place to exchange good ideas that may help us in caring for those we love that have this disease.
There have been a few studies on those men and women with MS and sex hormones. This post is going into depth on the topic of the research done with testosterone and Men (BIO-identical exactly same shape hormone as what your body produces. NOT synthetic that is a slightly different molecular shape).
I am one for researching the health options of my family and I think the best person that can advocate for your health is YOU. So I am posting research that you can read. If you feel it pertains to you then print the research and take it to your doctor...or not.
Either way best wishes to all of you,
EP
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MS and sex hormones
1.) http://www.ncbi.nlm.nih.gov/pubmed/19660660
"Both testosterone and estriol have been found to induce anti-inflammatory as well as neuroprotective effects. Findings from two recent pilot studies of transdermal testosterone in male MS patients and oral estriol in female MS patients are encouraging. In this paper, we review the preclinical and clinical evidence for sex hormone treatments in MS and discuss potential mechanisms of action."
2.) http://www.ncbi.nlm.nih.gov/pubmed/22209870
Neuroprotective effects of estrogens and androgens in CNS inflammation and neurodegeneration.
"This protection includes, but is not limited to, prevention of clinical disease, reduction of CNS inflammation, protection against demyelination, and protection against axonal loss."
3.) JAMA and Archives Journals (2007, May 14). Testosterone May Help Men With Multiple Sclerosis.
I am one for researching the health options of my family and I think the best person that can advocate for your health is YOU. So I am posting research that you can read. If you feel it pertains to you then print the research and take it to your doctor...or not.
Either way best wishes to all of you,
EP
------------------------
MS and sex hormones
1.) http://www.ncbi.nlm.nih.gov/pubmed/19660660
"Both testosterone and estriol have been found to induce anti-inflammatory as well as neuroprotective effects. Findings from two recent pilot studies of transdermal testosterone in male MS patients and oral estriol in female MS patients are encouraging. In this paper, we review the preclinical and clinical evidence for sex hormone treatments in MS and discuss potential mechanisms of action."
2.) http://www.ncbi.nlm.nih.gov/pubmed/22209870
Neuroprotective effects of estrogens and androgens in CNS inflammation and neurodegeneration.
"This protection includes, but is not limited to, prevention of clinical disease, reduction of CNS inflammation, protection against demyelination, and protection against axonal loss."
3.) JAMA and Archives Journals (2007, May 14). Testosterone May Help Men With Multiple Sclerosis.
A1.) ** http://www.ncbi.nlm.nih.gov/pubmed/21386088
Testosterone replacement in hypogonadal men with type 2 diabetes and/or metabolic syndrome (the TIMES2 study).
"Over a 6-month period, transdermal testosterone replacement therapy (TRT) was associated with beneficial effects on insulin resistance, total and LDL-cholesterol, Lpa, and sexual health in hypogonadal men with type 2 diabetes and/or MetS."
A2.) ** http://www.ncbi.nlm.nih.gov/pubmed/16728551
Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes.
"Testosterone replacement therapy reduces insulin resistance and improves glycaemic control in hypogonadal men with type 2 diabetes. Improvements in glycaemic control, insulin resistance, cholesterol and visceral adiposity together represent an overall reduction in cardiovascular risk."
A3.)** http://www.ncbi.nlm.nih.gov/pubmed/20092788
Testosterone replacement therapy improves insulin sensitivity and decreases high sensitivity C-reactive protein levels in hypogonadotropic hypogonadal young male patients.
A4.) **http://www.ncbi.nlm.nih.gov/pubmed/17954419
Effect of testosterone on insulin sensitivity in men with idiopathic hypogonadotropic hypogonadism.
"Insulin sensitivity improves and body fat mass decreases with long-term testosterone replacement therapy."
A5.) http://www.ncbi.nlm.nih.gov/pubmed/10857940
Testosterone, sex hormone-binding globulin, and the development of type 2 diabetes in middle-aged men: prospective results from the Massachusetts male aging study." low levels of testosterone and sex hormone-binding globulin (SHBG) play some role in the development of insulin resistance and subsequent type 2 diabetes."
A6.) http://www.ncbi.nlm.nih.gov/pubmed/18832284
Low testosterone and the association with type 2 diabetes.
A7.) http://www.ncbi.nlm.nih.gov/pubmed/15111517
Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men.
B1.) http://www.ncbi.nlm.nih.gov/pubmed/19020265
Men's health, low testosterone, and diabetes: individualized treatment and a multidisciplinary approach.
"Data suggest that testosterone therapy may have a positive effect on bones, muscles, erythropoiesis and anemia, libido, mood and cognition, penile erection, cholesterol, fasting blood glucose, glycated hemoglobin, insulin resistance, visceral adiposity, and quality of life. Sexual health may be a window into men's health"
B2.) http://www.ncbi.nlm.nih.gov/pubmed/16728551
Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes.
Me- So testosterone replacement is not only lowering blood sugar but improving cholesterol (fat) levels too.
1.) Memory problems for men(could also be low B vitamins, low thyroid or poor circulation)
2.) fatigue (can also be low cortisol if at night, low thyroid if in morning or growth hormone if mild fatigue throughout day)
3.) muscle sagging or atrophy (low growth hormone affects this too)
4.) low libido
5.) belly fat (too much stress[cortisol] and insulin imbalances affect this too. Obviously too much food and too little exercise affects this too.)
6.) depression
Just because you have MS does not mean you should no seek treatment for hormone imbalance symptoms.
If you feel any of this pertains to you then speak to an experienced bio-identical endocrinologist.
Best wishes,
EP
Declining testosterone levels in men not part of normal aging, study finds
2.) http://www.slu.edu/x38970.xml
Low Testosterone Linked to Alzheimer’s Disease
3.) http://www.reuters.com/article/2011/11/01/us-heart-disease-idUSTRE7A072V20111101
low levels of the sex hormone might raise men's risk of dying from heart disease.
4.) http://jcem.endojournals.org/content/94/7/2353.long
Lower Testosterone Levels Predict Incident Stroke and Transient Ischemic Attack in Older Men
Just because you have MS does not meany you don't have other health issues that need to be addressed such as low testosterone which can have many other negative effects on your body. If you feel this pertains to you then print out the research and discuss your options with your doc.
EP
Testosterone Replacement Reduces Mortality by Jeffrey Dach MD
http://jeffreydach.com/2012/04/04/testosterone-found-benefical-for-diabetes-by-jeffrey-dach-md.aspx
Testosterone research listed out -Testosterone reduces glucose (sugar) and bad LDLs in blood.
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http://jeffreydach.com/2012/07/13/healthy-men-should-not-take-statins-says-jama-by-jeffrey-dach-md.aspx
Why men should NOT take Statins (me- if you do you better be on CoEnzyme Q10)
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