i started LDN a year ago last April, using a local compounding pharmacy. I immediately saw bladder, fatigue and temp fluctuation improvements and gradually saw some return of use of fingers and toes. (I am in a wheelchair, no longer have use of legs.)

When I got a new script at 6 months, I sent it to Skips in Florida and saw a return of symptoms, but I stuck with in and after a few weeks all was good again. When I went back to my doc in Feb, I went back to local pharm and saw return of symptoms, but I thought if I hung on all would be good. Instead I got worse and worse. Back to bladder urgency and less use of fingers. I blamed this on a month long allergy bout and stuck with my script.

When hot weather hit and I was so weak, I called doc for new script which I sent to Skip. Now day three, my bladder is good and I can use my fingers better. I think the local pharm is using old naltrexone as they do not have many customers for LDN. I refilled twice and it never got better.

Also, the first day on Skip's I took it in the afternoon as some have mentioned here, and it did nothing for my symptoms.