Group News

Imagine mental illness, 2040.  An eleven year old boy has a family history of bipolar disorder.  A doctor's visit offers technology that determines the risk of developing a mental illness.  The physician conducts a memory task together with brain imaging and a genetics test.  The data is crunched in a computer that objectively concludes that the boy is highly at risk for, but has not developed, bipolar disorder.  Given the boy's genetic make-up and various environmental and social factors in the boy's electronic medical record, a computer prints out an individualized treatment plan focused on preventing the development of bipolar. In subsequent visits, the boy is analyzed for the earliest hint of bipolar disorder even before symptoms begin to occur.  If the illness does indeed develop, a specific and safe treatment plan is prepared based on the uniqueness of the boy's genetic make-up and environmental context.  This individualized therapy does not merely control symptoms, but directly combats the onset and root of the illness.  Throughout, his childhood is barely interrupted, and he gets along well in school.

Sound like pure fantasy?  Well, I have to stop and confess.  This whole paragraph has been stolen from a recent US News and World Report article about the understanding of the genetic underpinnings of illness as a giant step toward personalized medicine.  However, the US News story was written about cancer.  I just basically replaced any mention of cancer with a reference to bipolar disorder.  But, this is to make a point.

The US News article describes "an entirely new approach to diagnosis and treatment: "personalized medicine," which looks to a patient's unique genetic differences to better understand his or her illness and tailor care."  This revolution in diagnosis and treatment will bring about new discoveries, new therapies and new hope for cancer...  AND mental illness.

The National Institute of Health reports that current mental health research is "discovering how individual differences in biology could determine how that person reacts to a certain medication. Discovering these individual differences will help improve both diagnosis and treatment. For a person with mental illness, one can imagine that in the future a physician would perhaps use a memory task together with brain imaging and a genetics test to diagnose and select a specific treatment — just as a contemporary cardiologist uses a stress test and echocardiogram to diagnose heart disease and select the proper treatment."

We are on the verge of significant advances that will move us closer to predictive, preventive, and personalized mental health care grounded in research. Genetics and neuroscience together are giving us the tools for predicting risk, validating diagnosis, and identifying targets for new, more effective treatments.

So, I hope my point has been made.  Even though the media touts "personalized medicine" in the context of anything but mental illness, it applies here.  Next time you see an article like "Breaking Cancer's Code," smile and take heart, because the same techniques, technologies and understanding apply to breaking mental illness's genetic code too.  According to a recent article, "painstaking analysis of the DNA of thousands of patients has yielded important, and surprising, insights into the roots of schizophrenia, bipolar disorder, and autism."    It is important to understand, however, that researchers are just beginning to put together the pieces of a huge jigsaw puzzle of psychiatric genetics.  With further understanding and scientific discovery there indeed will be a revolution of diagnosis and treatment that will offer new hope, discoveries and new therapies.   So, even if you don't read about it in national publications, know that mental health research is offering hope for a better tomorrow.

 

- Support Mental Health Research at everyminute.org -

We have discovered suicide's genetic key.  "Canadian researchers may have discovered the underlying cause that leads some people to commit suicide or suffer major depression, a finding that could revolutionize how mental disorders are treated." The study describes chemical modifications in the brains of people who commit suicide as a result of major depression.  Researchers found that a gene that played a major role in controlling anxiety and stress was shut down in the cells of these brains.

John H. Krystal, M.D., Editor of Biological Psychiatry, comments, "This is exciting new evidence that genetic and environmental factors may interact to produce specific and long-lasting modifications in brain circuits. Further, these modifications may shape the course of one's life in extremely important ways, including increasing the risk for major depressive disorder and perhaps suicide."

The authors of the study say that this discovery may lead to major breakthroughs and a revolution in the treatment for mental disorders.  This will open an entirely new avenue of research and potential for therapeutic interventions.

"If we can give a drug that provides this long-term relief, I think we're on to something much more effective and perhaps at the root of the illness," said Dr. Poulter, lead researcher and professor in the physiology and pharmacology department at the University of Western Ontario. "There might be a whole new class of antidepressant drugs out there within a few years."

There is major potential here in the emerging field of epigenetics that examines how genes are turned on and off.  This research offers great hope for better mental health treatments and suicide prevention.  You can tell that the researchers are excited about these new discoveries.  We have to make sure that we support their efforts.  For some of us it may be a matter of life and death.

 Ladies and Gentlemen,

 

We are nearing 1,000 signatures!  One thousand signatures proclaiming that recovery is possible. Declaring that now is the time to accelerate mental health research for our children. 

 

Sign your name and volunteer to get involved in advocacy. 

 

Now is the time for us to fight back to defeat mental illness and prevent suicide.

 

Hope all is well,

 

Jace