Pediatrician
Dr Shapiro completed his undergraduate education at UC San Diego earning a B S in Biochemistry and Cell Biology and a B A in Political Science He furthered his education at UCLA where he earned a Masters Degree in Public…
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The History Behind the MMR Vaccine Controversy
Posted in ADHD / ADD by Dr. Jeremy F. Shapiro on Feb 11, 2009

I do hope by this time those who have come across my writings realize I try to maintain a balanced perspective on things.  Sure, a common premise I live by and one I enjoy promoting involves the role parents and caregivers should be playing in their children's lives, but frankly, I'm pretty sure most agree parents need to be firmly involved in the lives of their children.  But by and large, my intent is to listen to others, respecting all viewpoints and opinions, because, at the end of the day, we all have something to learn from one another.


So with this principle in mind, I have extended it to include the controversy surrounding vaccines...in particular the Measles-Mumps-Rubella (MMR) vaccine...and autism despite the significant amount of research disproving any association.  However, what infuriates me to this day is how the controversy appeared to evolve from a personal agenda rather than good solid scientific research.  And therefore, when I came across a recent article in the Times Online (http://www.timesonline.co.uk/tol/life_and_style/health/article5683643.ece), I must admit a sad smile came across my face as it appears a personal agenda was at play.


But before jumping ahead, I'd like to remind you all of exactly what sparked this controversy in the first place.  Approximately eleven years ago, a research article appeared in The Lancet spouting the claim that the families of eight out of 12 children felt their children's development of autistic-like characteristics was to be blamed on the MMR vaccine as they occurred shortly after its inoculation.  Furthermore, and possibly more interestingly, the researchers also described an association between gastrointestinal disease...some type of inflammatory process...and these behavioral symptoms in all twelve of the children. 


And so the release of this one article, with its roots in a single hospital in Great Britain and a population size of just twelve, ignited a world-wide debate that continues to this day.  It has clearly led to decreased rates of MMR vaccination and increased numbers of measles cases...take, for example, in England and Wales there were nearly 1,350 cases (with two deaths) diagnosed in 2008 compared to just over 50 cases in 1998.   And more than enough research has been produced over these last ten years to refute these orginal claims where I believe some of the resources could have been better used to study the complexity of autism and its related disorders.


But before I deviate further, I would like to share the most recent developments surrounding the article and its three remaining authors as ten of the original 13 gave a partial retraction in 2004, and accordingly, removed themselves from the original article.  So while I refer you to the Times Online article for complete details, the short of it is the remaining researchers have been charged by the United Kingdom's General Medical Council (GMC) of changing and misreporting results in their research.  Specifically, the investigation by the GMC has noted only one of the 12 cases appeared to have behavioral problems shortly after the MMR inoculation and, per the hospital pathologists, most of the cases had a normal gut and not an inflammatory process at the time of examination.


So while I do feel some vindication of what will probably become of the authors of this study, it is a sad smile in that I think of all the damage that has resulted since the article was first published.


 


Dr. Jeremy



Displaying comments 17-1 of 17
17
You need to write a diffinitive, theoretical esay with a clear and consice hypythesis and submit it to the general sientific concencious.
By AtticusFinch  Feb 18, 2009
16
I believe the scientific and medical communities have done a great disservice by not including anecdotal evidence in their case studies, and may even be ignored purposely. There are countless parents out there with heart-wrenching stories and first-hand evidence that falls on deaf ears, because they are one of those "radical" people against vaccinations. Doctors do not log this information because they don't believe it can happen. Just because scientists cannot replicate experimental data does not mean we discredit entire studies. Unfortunately, there is little pure objectivity out there. It has been estimated that only 1 in 10 vaccination related "brain damage" cases is officially diagnosed and entered into the system. Most cases are not bad enough to get the "autism" or other label and logged, or are misdiagnosed. Then again, there are so many labels out there that the data is watered down. Again, the causes are never determined. I know of many parents who have stated: "I just know they (vaccines) did something to my child!"

If you are interested in understanding possible causality, check this:

http://articles.mercola.com/sites/...

Mainstream doctors and scientists continually discredit the loads of research and evidence in this area, but cannot provide science backed causality themselves. Who can you believe? I am not against vaccinations in themselves, but how they are being administered as well as the propaganda around how they are safe and effective. There is no long term evidence that vaccines are safe and effective for everyone. If the risks/benefits were honestly explained to you, you would not get them for your child. You would, at minimum, wait until your child matured. The risks are reduced after a child starts maturing.

The real problem is there are government and social agendas already in place, and will not be changed easily. Proponents of mandatory mass vaccinations only view this problem at a macro scale: it appears to stop endemics and epidemics. Short of our children falling over dead in the clinics, there will be no change. For proponents, the end justifies the means. They expect some percentage of casualties as a result of these programs. Otherwise, they wouldn't have the vaccination court and VAERS vaccine side effect data logging site. It is all for the perceived "greater good". The drug companies love it because they won't be sued! We are living in the new world order, folks. Get used to it.
By skobs  Feb 17, 2009
15
Things need to be put in perspective. Always question statistics! Statistics only prove data correlation. They can NOT prove causality. Anything can be proven or disproven by statistics. I've always tried to be empathetic to both sides of an argument. Whenever a study is performed, you must understand the motive behind it and who performs it. Usually, there is a motive behind these studies. I could prove with 95% confidence (standard statistics) that a study's data correlates...that is of course after normalizing data and strategically removing outliers and one-offs. I have a science and engineering background. My answer to people about statistics is always: SO WHAT!? I can make the data look any way I want, and it is done in industry all the time! Prove to me causality..."What is the root cause?". Statistics only provide a you with some confidence that your theory or assumptions are correct, not that statistics prove any causality in and of themselves. Obviously, this works both ways.

These vindication studies are justified as in a court of law: found "not guilty". This in no means proves innocence. O.J. was also found "not guilty".

Root cause is usually not about a single factor only. If the MMR vaccine is studied in isolation, you only get part of the story. The MMR vaccine used to contain Thermisol (mercury based) and now uses Aluminum. Some vaccines still use Thermisol. There is no question that mercury and aluminum (at the doses administered) are toxic, especially to infants. Statistics are irrelevant at this point! Now you need to look at potential effects of these toxins and also when delivered at a given age and in combination with other factors, such as other vaccines, environment, diet, and genetics (predisposed conditions and vulnerabilities). Vaccine loading is likely more significant than a MMR vaccine in itself. A key factor for infants is swelling of the brain after vaccination. This factor can cause all kinds of neurological problems and side effects. Autism is just one small piece of this picture, and the reason why correlation is difficult.

There is always more to a story than what is on the surface. What about the combination of other toxic exposures in our food, water and air, as well as the deficient diets our kids are raised on. Remember, there is ALWAYS a root cause! The westernized world is more diseased and sicker than ever before. Our government and general medical community have chosen to ignore this fact, because they are only focused on their grandiose social goals...and stuffing pockets with cash. Stop with the statistics and fix the problems!

Example: I can prove with 95% confidence that software I write works as designed. I run lots of tests and collect data. But I know that I have never tested the design thoroughly, even though it had some odd behavior at times...just thrown together and then checked if it worked. No big deal you say! Well, this device happens to deliver drugs to a patient. 1 out of every 100 patients is harmed or dies due to a minor malfunction that delivers an overdose. But I can statistically prove, with high confidence, the software works! Is that good enough?
By skobs  Feb 17, 2009
14
My son was perfectly normal...then he developed autistic like tendencies...and he is now delayed emotionally. I think there is some truth in this and would like to see more research done before we write it off as coincidence. If I were to have another child I would choose to NOT vaccinate. And would feel I was doing what was best for my child.
By laurelbooks  Feb 16, 2009
13
It seems to me there is an intensely personal agenda here - every single person I know who has not had their child MMR immunised or who believes there is a link to autism (myself included), has a personal story to tell. They know of someone who has a child or they have a child who has developed autistic behaviour as an obvious result of the MMR vaccination. My children have all had every other vaccine recommended just not the MMR - I am not opposed to vaccination, just combined vaccines and as the single vaccines exist why are we not given the option of single vaccination? beacuse it costs more, thats why. This is the saddest part of it all.
By RebeccaLacey  Feb 14, 2009
12
http://www.globalresearch.ca/index... This is the link to Morgellons Disease and the connection to agrobacterium.
By SharonHanson  Feb 14, 2009
11
I'm sorry I have to disagree with you Dr. Shapiro. I have been mold exposed and had to endure the political consequences of being sick from a political disease. Ever since research has been privatized we are not getting unbiased answers to healthcare questions. If fact these rigged clinical trials are only obfuscating true causes of disease. This website maintained by Ivy League MDs shines a light on the corruption in clinical trials. http://www.ahrp.org/cms/content/vi... And other political diseases also shine a light on the corruption in the healthcare and insurance industries. Take Lyme disease or mold illness and you can see quite clearly how the CDC and insurance companies are covering up the true nature of this illness. It took me five years two or three near death experiences with adrenal crisis to get diagnosed. But most doctors don’t have a clue about Lyme disease or mold illness. Aspartame is another example of a product that should be banned but isn’t because the corporations that make it have an enormous amount of power over our politicians. And how about genetically modified food? It’s recently been found that the bacteria used to transfer the gene or protein has not been killed and it has gotten into our soil. This mutated bacteria they believe is causing Morgellon’s Disease. http://www.ahrp.org/cms/content/vi... . How is it that Monsanto can inject their seed with a protein that makes crops from Monsanto’s seeds resistant to their RoundUp Ready herbicide? The farmers can spray their GM crops extensively with RoundUp Ready herbicide and the plants don’t die. But we will and so will the bees which they believe are dying due to all the herbicide being sprayed on these plants. I don’t trust what they say about vaccines and I will never get another one and I’ve convinced my daughter if she has children to go lightly on the vaccinations. It could be just one factor in autism but until we get some unbiased studies I’m not buying anything they say.

Did you hear how the pharmaceutical companies and medical device manufacturers were lobbying to ban research that would help determine what medical treatments work best? Dr. Shapiro I think doctors need to unite and stop the conventional medicine insanity that currently exists. We need answers now and the pharmaceutical companies and insurance companies are not going to provide us with unbiased answers.
By SharonHanson  Feb 14, 2009
10
What bothers me about this is the fact that I watched my neighbors two grandchildren go through the Autism.... What is also disturbing is the fact that after they began to get better the booster shot put them right back into the original problems. What explanation can be given for this I wonder.....Thank You
By ClaudiaD  Feb 13, 2009
9
what about the study regarding newborn monkeys who received all the vaccine doses our children receive and were showing neurological disorders and s&s of autism? The control group (unvaccinated) showed no signs and symptoms of autism.
Personally, I believe all these parents who claim the vaccine caused autism. Moms know what did it as well as Jenny McCarthy knows what did it to her son.
Not a single vaccine company has asked the government for a bailout. mmmmmmmmm..............
By sisterof4gals  Feb 13, 2009
8
Comparing vaccines to cigarettes- that sickens me. Unfrickinbelievable. I am old enough to have seen children DIE from measles. I've seen children DIE from pertussis. I have friends who have recovered from Polio with lifelong deformities. PLEASE, give us a break and get real.
By pianogirl  Feb 13, 2009
7
I thought this article might fit well here:

http://health.usnews.com/articles/...

Paul
By PaulDS  Feb 13, 2009
6
Thanks Dr. J!!!
The Lancet is not as highly regarded like Science, Nature, NEJM and JAMA... Every now and then The Lancet does crank out highly peer reviewed scientifically interrogated articles. Of course, 10 years ago, Lancet did have an excellent editorial board...
The other issue is autism is a polygenetic disorder with quite a bit epigenetics that needs ferreting out. With hap-maps and genome wide windowing, the array tech could prove beneficial, although there will be terabytes of info to map and more statistics that we have develop, beyond Bayesian analysis.
That all says, these last 8 years, there has been no money to do research, period. So, our minds have not been on a quest to solve these issues.
That is why I no longer do research... However, health issues are only going to increase over time.
Dr. G-
By AKAMonet  Feb 12, 2009
5
No, it does not appear to me that you are trying to maintain a balanced perspective when it comes to vaccines, otherwise you would not report on an article written by Brian Deer without disclosure of who Brian Deer is. Here is a response to that article by journalist Melanie Phillips:

http://www.spectator.co.uk/melaniephillips/3346281/the-witchhunt-against-andrew-wakefield.thtml

Here is an excerpt from her article:
"What the Sunday Times did not report was that the GMC investigation into Wakefield was triggered by a complaint from... Brian Deer, who furnished the allegations against him four years ago. He has thus been reporting upon the hearing into his own complaint. Since when has a reputable paper published a story by a reporter who is actually part of that story himself -- without saying so – and who uses information arising from the disciplinary hearing which he himself has instigated and which is investigating allegations he himself made in the first place?"
That same article contains a response by Dr. Andrew Wakefield to the allegations.

Your infuriated that the controversy evolved from a personal agenda (meaning Dr. Wakefield)? I think you need to give parents more credit than that. If you want to give credit to the evolution of the controversy, you may want to credit the internet - because that is how thousands of parents discovered so many others that had a remarkably similar story to tell - an apparently healthy child went in for a shot, became very ill with chronic gastrointestinal problems and stopped communicating. There are a lot more than 12 children. My two autistic nephews both have severe chronic gastrointestinal problems and the pediatrician of one nephew told his mother 'it's just the autism'. It seemts that even pediatricians are aware of the strong correlation of gastrointestinal problems to autism. It is also noteworthy that there have been numerous recoveries from autism by addressing the gastrointestinal issues. The strongest gains in my one nephew (who is 10) has occurred in the last two months after beginning the gluten/casein free diet, along with antifungals and probiotics.

If you were truly maintaining a balanced perspective, then you would reserve your sad smile not only for the damage resulting from non-vaccination, but also for the damage done by vaccination, for there are casualties on both sides.
By SparkyKC  Feb 12, 2009
4
Dr. G-My apologies if my words are confusing but what I am bothered by is this one study with only 12 cases ignited a controversy that still continues to this day...particularly in light of these new allegations directed at the lead researcher of the study. I also agree with your point we have to try harder.
By DrJeremy  Feb 12, 2009
3
Dr. J, I am not sure if I understand what you are saying... If I may, are you saying you are quite infuriated about the recent developments of scientific misconducts as a result of the vaccinations that were thought to "cause autism"? If so, I do respect your anger and as a scientist I can tell you, "groupthink" and politics are well endowed with research these days... If not, it sounds as if there is fear because all this research for over a decade has not led us any closer to the mechanism to understanding autism, much less other behavioral disorders... Which means, we all have to try harder... We are grasping for something that can tell us "why" when maybe, there is no "why"... How can we tell sufferers, patients in your case, to move beyond that thought process? We use empathy...

Dr. G-
By AKAMonet  Feb 12, 2009
2
you know there is no "scientific evidence" that there's a link between cigarette smoking and lung cancer or emphysema, but only a knuckle headed moron would belive that cigarette smoking does not causes these diseases. what if there is a link between the vacinations and autism. if there's currenly no evidence supporting these claims, there's certainly no evidence showing that the vacinations are safe.
By ghur4  Feb 12, 2009
1
Bravo, Dr. J. You get a standing O from me for this one. I have spent SO much energy and time fighting the hype created by these people I am thrilled to see they will be receiving some sort of backlash at long last. My heart truly goes out to parents of autistic children who have no good answers in regard to a cause and limited proven treatment options, but this misguided finger pointing has done so much more harm than good, and there is a large section of the population who refuses to see that.
By pianogirl  Feb 12, 2009
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