Pediatrician
Dr Shapiro completed his undergraduate education at UC San Diego earning a B S in Biochemistry and Cell Biology and a B A in Political Science He furthered his education at UCLA where he earned a Masters Degree in Public…
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Shedding Some Light on Melamine
Posted in Adoption by Dr. Jeremy F. Shapiro on Nov 30, 2008

Earlier this year, Chinese authorities found large levels of a potentially harmful chemical in many of its milk-based products...including its infant formula and milk.  By now, many are well aware that this compound is melamine, which led to thousands of hospitalizations and a number of deaths in China.  Worldwide panic ensued, but at the time, the concern in the United States was minimized as Chinese manufacturers were not licensed to sell infant formula in the U.S.  Of course, this did not preclude its use here in the U.S, but to date, no Chinese manufactured infant formula has been found on the shelves of U.S. markets.


Now fast forward to this past week where reports surfaced that the U.S. Food and Drug Administration (FDA) recently performed tests on infant formula made by U.S. based manufacturers.  And although unable and disappointed I cannot locate these results on the FDA website, many news agencies reported the results of the findings (under the Freedom of Information Act)...which found melamine in the formula of one manufacturer and a related compound in the formula of another manufacturer.  And, of note, a third has since done its own testing which did find trace levels of melamine in its own formula.  With these three companies accounting for more than 90% of all infant formula produced in the U.S., the panic button has been sounded again as evidenced by what I am witnessing here at Daily Strength, in my office, and in many of the local parenting groups in my own community.  So I thought now would be a good time to shed some light on these recent developments.


But what is melamine?  Melamine is a very small molecule used in a variety of industrial products, including its use as a flame retardant and as a component of a variety of every day products ranging from cooking utensils to paper.  However, it should be noted that melamine and its related compounds...cyanuric acid, ammeline and ammelide...are not approved for use in human and animal food here in the U.S.  The concern arises when there is exposure to high levels of melamine or when melamine and its related compounds exist together at lower levels.  Under these conditions, there is potential for the development of urinary tract problems...primarily, kidney/urinary tract stones and ultimately, kidney failure. 


How has the FDA responded?  Well, after what appeared to be extreme reluctance by the FDA in determining and providing safe exposure levels over the last couple of months, a threshold was just released two days ago...1 part per million of melamine in formula...with the caveat that no related compounds (cyanuric acid, ammeline, and ammelide) are present as well.  And although it is not clear as to how this level was established, it is the same threshold used in Canada and China and happens to be significantly above the trace amounts recently detected and described above. 


And what am I telling my patients?  Something, I am sure, many of you are interested in.  I begin with reminding parents that the problem in China allegedly evolved from directly manipulating melamine levels in order to increase the overall protein level in formula...an ethical and disturbing no-no.  In the U.S., melamine is forbidden to be added as a food ingredient, but it appears it can be found in trace amounts of food (infant formula included) as melamine is used in products related to the food preparation process.  And while the circumstances in which the FDA quickly responded with a threshold level just a couple of days ago may generate further questions and concerns, at the present time, I am not changing any feeding practices for the infants in my practice who rely upon the nutrition of infant formula.   And to further that point, my response to the question that my parents often ask and take comfort in, I would make no changes if it was my own child.


Questions?  Concerns?  I'd love to hear them.


 


Dr. Jeremy



Displaying comments 15-1 of 15
15
I would like to add that my own daughter, who just turned 6 years old, got deathly ill after eating halloween candy. Her pediatrician told us that it was the "flu", but I knew it wasn't the flu. She didn't have any fever, but she refused to eat, she refused to drink, and all she wanted to do was lay on the couch and sleep. She lost a lot of weight and became extremely lethargic. Eventually the pain in her belly was so bad that we had to take her to the children's hospital, where we found out some really bad news. She had thousands upon thousands of crystals in her urine, and lots of blood. Turns out the melamine contaminated candy had all but destroyed her kidneys and urinary tract.
This just happened right before thanksgiving 2008. She is still not very well, still recovering from the damage of the drug melamine, which I believe she received from halloween candy. We live in Virginia, and it makes me wonder how many other kids were sent home from school, or by their doctors, saying that they had the flu, but nobody bothered to test their urine to find out the real culprit after halloween.
By Iluvmybabies  Dec 10, 2008
14
Willow,
I'm sorry to hear of the problems but foods produced in the U.S. are prohibited to use melamine.
Dr. Jeremy
By DrJeremy  Dec 03, 2008
13
I am curious, can this effect adults from any foods here in the US? I ask because, at the present am trying to chase down a kidney problem? Probably does not having anything to do with it, but I thought I would ask :)
Sincerely,
Willow54
By willow54  Dec 03, 2008
12
I've been wondering about the plates that my son is eating off of that are made of melamine. Is it safe since it's in a solid form or could small amounts come off? I must add that my son has already had lead poisoning from plates I was eating off of and then breast feeding him. So that history makes me a little more nervous.
By hthomas98  Dec 03, 2008
11
I recently bought some turkey jerky that is processed in china.Is there any reason to be concerned about melamine in this product?
By chatman  Dec 02, 2008
10
Reason #3056 to promote breastfeeding! I appreciate you sharing what you tell your patients. I am struggling with an avalanche of phone calls on this issue today.
By pianogirl  Dec 01, 2008
9
"On Friday, an FDA official said it was still not possible to determine a safe level for infant formula containing both melamine and cyanuric acid compounds, but officials "believe that at very low levels there should not be any health concerns."

Should not be any health concerns? Aye.
Is zero percent melamine and cyanuric acid compounds an impossibility?
By DLR77  Dec 01, 2008
8
Firstly I think we should all realize that toxic substances are everywhere and there's really no way of avoiding them entirely. They're in the air, the water and of course from there they get into the food chain because everything we eat has to have air and water to grow.
That said I think that it's really sick the way the FDA first says they cannot establish a 'safe' level for melamine in formula, THEN as if by magic, comes up with one.
I also think it's hyppocritical for them to say that formula that contains melamine is safe when they're up at arms about kids having PETS in the house.
I'd suggest getting formula from health food companies where they're more careful about what goes into their products.
By ALC67  Nov 30, 2008
7
I live in Canada and there is also disturbing news about pertrollium based products and items used in everyday products that has been proven to harm especially male fetisus. Whats even more disturbing is that the companies that manufacture these products says there is no proof and quotes its own studies by its own scientists. Can you say confict of interest? Especially when all the other studies are saying the opposite of these companies. Its amazing what greed will do. Here's the documentary

http://www.cbc.ca/documentaries/do...
By supermanreturns  Nov 30, 2008
6
thank you..... you have put my mind at ease. i have to beleive if it were harmful, my gut would tell me. thank you for the response.
By toosoon  Nov 30, 2008
5
My thoughts too on homemade vs. store bought formulas is that you have morons who can't read a label and mix the store bought right either....been there and saw that too many times in my years as a child care provider...either they have made it so watery you can tell they are trying to be cheap...or you have those folks who think if 2 scoops is good than 4 is better hahahaha then you got this poor baby who should be drinking their bottle with a straw because its so thick....hehehehhee just gotta be a smart azz and add that one!
By NickNicksmommykitkat  Nov 30, 2008
4
I would like to think all pediatric caregivers are aware of the recent formula findings. Regarding homemade formulas, my biggest concern is when they are not mixed appropriately, which can lead to significant nutritional and health issues for the infant. To date, I do not have any parents making their own formulas.
Also, Dee, I do not believe there will be a recall based on the current findings by the FDA. The levels would indeed have to be higher.

Dr. Jeremy
By DrJeremy  Nov 30, 2008
3
Thank you Dr. J, it's just many of us over in the SIDS boards have recently had babies, are pregnant or TTC again. It's just really scary being a parent who has already lost one child to BS to hear about this melamine crap when I have a 12 day old baby here. I definitely appreciate your writing on this. Right now, my little girl gets 50/50 bottles half breat milk, half formula. I too am curious on your take on homemade formulas, I am also going to be checking with my pediatrician too, but just want to hear your take on it....thanks again!
By NickNicksmommykitkat  Nov 30, 2008
2
thank you..... should i contact my peditrician and alert him to the fact that one of the formulas in question is what i am using for my 3 month old son? just in case there is a fever or infection, in the future. and what is your take on home made formulas? such as ones made with evap milk, sterile water, and molases? and do you think there will be a recall?
dee
By toosoon  Nov 30, 2008
1
thats sick that all those kids familys had to suffer that way... may god bless them all.
By godsheavenlyangel06  Nov 30, 2008
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