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Discussion:
Progesterone and Pregnancy
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Hi there ladies!!
I wanted to post this in case it happens to be relevant to any women on here.... I have a luteal phase defect (time between ovulation and period being less than 10 days) and subsequently cannot maintain a pregnancy without natural progesterone suppliments.

Taken from http://www.askdramy.com/preventmis...:

"There is a small group of miscarriages that can be prevented. These miscarriages are causes by a progesterone deficiency (luteal phase defect). Progesterone is needed to support the growth of a pregnancy. In the early weeks of pregnancy, the mother’s body produces the progesterone. By about 8-9 weeks of pregnancy, the placenta usually takes over the production of progesterone. Women who don’t produce enough progesterone in the early weeks of pregnancy may have repeated miscarriages. These miscarriages can be prevented by progesterone supplements.

Only a small percentage of women have a progesterone deficiency. The most common symptom of progesterone deficiency is a menstrual cycle that is less than 26-27 days long. A progesterone deficiency can be diagnosed by tests done before you get pregnant. Women who do not have a progesterone deficiency will not benefit from progesterone supplements."

There is support for the use of progesterone in these cases. The Cochrane review (internationally highly regarded in the medical commumity as a source of evidence in regards to healthcare treatments) states that: "In a subgroup analysis of three trials involving women who had recurrent miscarriages (three or more consecutive miscarriages), progestogen treatment showed a statistically significant decrease in miscarriage rate compared to placebo or no treatment (Peto OR 0.38; 95% CI 0.20 to 0.70). No statistically significant differences were found between the route of administration of progestogen (oral, intramuscular, vaginal) versus placebo or no treatment."

This is not the most common of disorders, however if any of you have this (mine is a result of endometriosis) then progesterone supplementation can help you to both fall pregnant and maintain the pregnancy. It was necessary for me to use progesterone with my first pregnancy, and now I am needing progesterone and HCG to maintain my current pregnancy (we conceived twins but have since miscarried one). Since the progesterone is natural (identical to what the body makes) it is very unstable and comes in three forms: 1-injection 2-troche (dissolves in the mouth) or 3-pessary (inserted like a tampon). I just wanted to add this post in case any one on here is suffering recurrent loss and can be helped, as God blessed us with specialists who have helped us. Please contact me if you would like any further info. Best of luck to you all!
Posted on 11/07/09, 12:11 pm
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Reply #1 - 11/07/09  8:33pm
" Thanks for posting that! I have had 2 consecutive miscarriages and am currently only 7 weeks pregnant. My dr suggested I use the progesterone suppositories, as she said these are the most effective, and the shots hurt like hell. The dr never tested me for low levels of progesterone which I dont get, so who knows if I am even low on prgesterone. I am hoping I am, so that it works this time and keeps the baby inside of me! Either way, it can't hurt. "
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Reply #2 - 11/08/09  5:35am
" I will be praying for you :)
He is right, the shots do hurt... but not as much as the pain of losing a child, and I am so sorry you have endured that twice. I have my levels checked twice a week so we know how much to use. The pessaries cause me cramps (due to the endo) but are probably the best method if they don't! They are messy, panty liners will be your friend!! The progesterone absorbs, but the wax drips out over the next day or so.... it scared me at first because I wasn't warned, so if it happens to you it is normal (it looks like more comes out then you put in...) and they go in every night, so your hormone levels stay quite constant. The shots peak and drop, but get your levels much higher than the pessaries - this is why I need the shots. On the positive side, MOST women get to stop around weeks 10-12!!! :) I am not one of them, I need them the whole pregnancy. In your shoes, I would ask my doc to do a check once a week for a month or so after stopping the pessaries, just to make sure your levels have responded like normal and are raising. Any cramps, spotting or hardening of your uterus happens, get straight back onto him in case you need more progesterone. Congrats on your pregnancy and I will be praying that God gives you the strength to get through this xx "
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Reply #3 - 11/08/09  5:37am
" Oh, I wrote 'he' instead of she in reference to your doc :) Great to hear she is trying you on this treatment x "

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