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Hey you guys. Ive received some questions about this so wanted to post a basic discussion

1) MGUS is Monoclonal Gammopathy of Undetermined Significance
2) MGUS progresses to Multiple Myeloma at a constant rate of 1% per year (and the rate does not change with time)
3)In most patients MGUS does not progress to Multiple Myeloma and requires no therapeutic intervention

Here is how you diagnose MGUS and the distinction between MGUS and MM
1) A monoclonal paraprotein band that is high but NOT AS HIGH as in Multiple Myeloma (less than 3 g/dl)
2) Plasma cells less than 10% on bone marrow examination
3) UNLIKE Multiple Myeloma: MGUS patients have No evidence of bone lesions, anemia, hypercalcemia, or renal insufficiency.

Dr O.
Posted on 12/05/07, 05:33 pm
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