What is Migraine Headaches

Migraine is a neurological disease, of which the most common symptom is an intense and disabling episodic headache. Migraine headaches are usually characterized by severe pain on o...

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New Drug Cambia!!!
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There is a new FDA approved medication for acute migraine headaches called Cambia. Here's the info: The FDA has approved a new prescription medication for the acute treatment of Migraine attacks, Cambia, developed by Kowa Pharmaceuticals America (KPA). Cambia is a combination of diclofenac (brand name Voltaren), a non-steroidal anti-inflammatory drug (NSAID) and potassium bicarbonate. In clinical trials, Cambia was shown to be effective for adults who have Migraine with and without aura.
Cambia is a powder that's mixed with water for form a liquid medication. Clinical studies indicate Cambia may be a good first line medication choice for acute Migraine attacks due to its quick onset of pain relief. Patients and doctors alike agree that fast relief time is very important, and the trials show pain relief time in 15 to 30 minutes. In clinical trials, Cambia was shown effective in treating photophobia (intensified sensitifity to light), phonophobia (intensified sensitivity to sound), and nausea during a Migraine attack. Other symptoms during a Migraine may include dizziness, fatigue, and visual disturbances. Continue reading more about the possible phases of a Migraine attack and their associated symptoms in this article: Anatomy of a Migraine.
Posted on 06/30/09, 12:06 pm
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Reply #1 - 06/30/09  6:17pm
" WOW,.. that's great news. Thank you. "
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Reply #2 - 07/01/09  2:37pm
" Cambia (Diclofenac Potassium) - was previously called PRO-513
Here are two links on its history

http://www.drugs.com/nda/pro_513_0...

http://digital50.com/news/138959

Like so many migraine meds, It comes with some potential nasty side effects which are:

Diclofenac Potassium
In 718 patients treated for periods of 2 weeks or less, with Diclofenac Potassium immediate-release tablets, adverse reactions were reported one-half to one-tenth as frequently as by patients treated for longer periods. In a 6-month, double-blind trial comparing Diclofenac Potassium immediate-release tablets (N=196) versus diclofenac sodium delayed-release tablets (N=197) versus ibuprofen (N=197), adverse reactions were similar in nature and frequency.

In patients taking Diclofenac Potassium immediate-release tablets or other NSAIDs, the most frequently reported adverse experiences occurring in approximately 1%-10% of patients are:

Gastrointestinal experiences including: abdominal pain, constipation, diarrhea, dyspepsia, flatulence, gross bleeding/perforation, heartburn, nausea, GI ulcers (gastric/duodenal) and vomiting.

Abnormal renal function, anemia, dizziness, edema, elevated liver enzymes, headaches, increased bleeding time, pruritus, rashes and tinnitus.

Additional adverse experiences reported occasionally include:

Body as a Whole: fever, infection, sepsis

Cardiovascular System: congestive heart failure, hypertension, tachycardia, syncope

Digestive System: dry mouth, esophagitis, gastric/peptic ulcers, gastritis, gastrointestinal bleeding, glossitis, hematemesis, hepatitis, jaundice

Hemic and Lymphatic System: ecchymosis, eosinophilia, leukopenia, melena, purpura, rectal bleeding, stomatitis, thrombocytopenia

Metabolic and Nutritional: weight changes

Nervous System: anxiety, asthenia, confusion, depression, dream abnormalities, drowsiness, insomnia, malaise, nervousness, paresthesia, somnolence, tremors, vertigo

Respiratory System: asthma, dyspnea

Skin and Appendages: alopecia, photosensitivity, sweating increased

Special Senses: blurred vision

Urogenital System: cystitis, dysuria, hematuria, interstitial nephritis, oliguria/polyuria, proteinuria, renal failure

Other adverse reactions, which occur rarely are:

Body as a Whole: anaphylactic reactions, appetite changes, death

Cardiovascular System: arrhythmia, hypotension, myocardial infarction, palpitations, vasculitis

Digestive System: colitis, eructation, liver failure, pancreatitis

Hemic and Lymphatic System: agranulocytosis, hemolytic anemia, aplastic anemia, lymphadenopathy, pancytopenia

Metabolic and Nutritional: hyperglycemia

Nervous System: convulsions, coma, hallucinations, meningitis

Respiratory System: respiratory depression, pneumonia

Skin and Appendages: angioedema, toxic epidermal necrolysis, erythema multiforme, exfoliative dermatitis, Stevens-Johnson syndrome, urticaria

Special Senses: conjunctivitis, hearing impairment "
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Reply #3 - 07/02/09  1:12am
" lmfclcls,

Have you tried it all ready? I know you have tried many if not all the possibilities out there. "
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Reply #4 - 07/02/09  11:40am
" Yes - I tried it while it was in the experimental phase. I participated in a clinical study. "
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Reply #5 - 07/03/09  1:21am
" WOW, .. thanks. I think I would avoid it after seeing those possible side effects .. except I have had cluster headaches where I would have taken just about anything for relief. I am glad my Fioricet works. "
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Reply #6 - 07/07/09  5:24pm
" I was told about this new mwd about a month ago by one of my doctors. As a a hope for my migraines. But I am alleric to (NSAID's) so I guess this one is out for me to. Plus thay don't test these new meds long enough to really know the long trem affect of them anymore. So I will be staying away from this one to.
pepsi "

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