Hives Support Group

The skin lesions of urticarial disease is caused by an inflammatory reaction in the skin, causing leakage from capillaries in the epidermis, resulting in an edema which persists until the interstitial fluid is absorbed into the surrounding cells.

Urticarial disease are thought to be caused by the release of histamine and other mediators of inflammation (cytokines) from cells in the skin. This process can be the result of an allergic or non-allergic reaction, differing in eliciting mechanism of histamine release.

Oral antihistamines provide a good solution for acute urticaria. The medication will reduce the itching and help the welts disappear. Antihistamines mainly reduce sensitivity. Short term side effects include drowsiness, while long term side effects can lead to a less responsive immune system. In the case of chronic urticaria, a combination of H1 (ie, Zyrtec, Allegra, etc.) and H2 (ie, Zantac, Tagamet) antihistamines usually helps in these cases where H1 antihistamines alone do not give any results. In extreme cases a strong immunosuppressant such as prednisone may be prescribed. Oatmeal baths and anti-pruritic lotions can also be used to relieve the itching.