What is HIV
HIV (also known as human immunodeficiency virus, and formerly known as HTLV-III and lymphadenopathy-associated virus) is a retrovirus that primarily infects vital components of the...
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resistance to 90% of HIV meds
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how shit is this.. Ive been on meds only 1 year, positive for 9 years. results just in tells me pretty much all the drugs wont work on me anymore......love to here from people that have similar situation.. feeling really bumed out, sad and disolutioned....
shine some light into my darkness good people.... Posted on 05/22/09, 07:05 am |
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One of my areas of research is mutations in HIV-1 which result in drug resistance. There are basically 3 types or "classes" of antiretroviral drugs. 1) The Nucleoside analog reverse transcriptase inhibitors (NRTIs) such as dDDI and AZT. 2) The nonnucleoside reverse transcriptase inhibitors (NNRTIs) such as Stavudine and Lamivudine. 3) Protease inhibitors.
There is also a fusion inhibitor (Raltegravir) and entry inhibitors (Enfuvirtide and Maraviroc). Some drug resistance mutations create viruses that are resistant to more than one drug. Some create viruses that are resistant to one drug and extra sensitive to another drug. Some create viruses that are resistant to a drug, but crippled so they replicate very slowly. The bottom line is that not all drug resistance mutations are equal, and quite often the drugs continue to work very well even when the patient has drug resistance mutations detected in their virus gene sequences. It is often more important to consider viral load and CD4 count and other factors, than viral genotype, when considering whether or not to switch medications. The International AIDS Society Drug Resistance pages: http://www.iasusa.org/resistance_m... has the most up-to-date information. Not all doctors understand all the issues related to multi-drug resistance in HIV, so it may be best to go to a real specialist for a case like yours. 
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Well that really is a toughie bud my heart goes out to you. It looks like things might not be as bad as they appear if I understand DrDuke correctly. Even though you have some resistance, continuing with a specially tailored med regime will keep the virus under control to levels that help you retain a cd4 high enough to keep on top of things and of course they can use prophylaxis drugs to combat the OI's at times when you're run down by colds and flu.
Stick around, we're here for you!
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Wow, been working with PWA's and trying to learn as much as I can for 16 years and it is sooo complex. As always, thanks Dr. Duke we are very lucky to have you here. And yes I agree you may need another, more knowledgeable doc, are you in a metro area or close to one? Our local hiv doc is not informed and we have to go to Los Angeles, local doc told us to go home and call hospice and gave partner 30 days to live 5 YEARS AGO....................................LOL
Point is right doc very important, don't give up, keep looking and asking questions, be proactive, I hope all turns out well for you, pls let us know what you find out.............................hugs
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