HIV Support Group

I have received many questions from members about this. This weeks Annals Of Internal Medicine (April 17,2007)has a review on Antiretroviral Therapy ro Prevent Sexual Transmission of HIV-1

Here are the salient details
1) Emergency ART is considered the standard of care after OCCUPATIONAL exposures to fluids or tissues (needlestick injuries, etc)
2) More recently, ART for prophylaxis after NONOCCUPATIONAL HIV exposures has been widely used and most countries have developed specific guidelines for its implementation
3) For obvious reasons...clinical trials in humans to PROVE thie efficacy of ART postexposure prophylaxis has not been possible
4) Experiments on Rheses macaques suggest that therapy must be offered as soon as possible after the exposure (within 72 hours) and must be continued for 28 days
5) Patients taking the combination of tenofovir-emtricitabine (Truvada) for post-exposure prophylaxis were more likely to complete the 28 day course than those taking 2 or 3 drug regimens containing zidovudine

Thoughts?
Dr O.
Posted on 04/27/07, 10:32 pm