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HIV (also known as human immunodeficiency virus, and formerly known as HTLV-III and lymphadenopathy-associated virus) is a retrovirus that primarily infects vital components of the...

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Advice:
Question re. blood brain barrier
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My doctor suggested today that I switch meds, and I have a questions about something she said. I should have mentioned it to her whilst I was there, but I only thought of it on the way home.

She mentioned that my new med will penetrate the blood brain barrier, which will be good for the long-term. I agree with this. However, I was a bit puzzled. If only one med -- my new med -- penetrates the blood barrier, then the medicine in my brain will be only ONE medicine, and not a combination... is that right? And if so, will the HIV in my brain become resistant to that medication because the other two components of my regimen are not getting through the barrier?

Any advice or comments would be much appreciated :)
Posted on 09/16/09, 05:09 pm
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Reply #1 - 09/16/09  11:16pm
" Well, you hope not to have much, or any, HIV in your brain cells to begin with. HIV can get into brain cells, and other nerve cells, but it is a lot better for you if it does not.

If the virus does get in there, and there are no drugs there, then it can replicate. If it gets in and there is a good inhibitory drug there, it can't replicate unless it develops resistance to that drug. "
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Reply #2 - 09/17/09  7:57am
" Although my #'s are great at this time, an initial genotype was done three years ago to test for resistance, and yes, as most newly infected do indeed have these days. Atripla has been my med and the Sustiva component of three drug regimine penetrates the blood-brain-barrier. She explained that *especially* since HIV initially attacked my central nervous system with peripheral neuropathy *BEFORE* starting any meds, that having a med to inhibit replication in brain would be my best option. She also stated that researchers believe that is why Sustiva induces some pretty wild dreams. My first night on Atripla I had a dream that a Serbian pregnant woman was chasing me around with a butcher-knife, swearing it was my baby! Being 100% gay, this was pretty strange. I still have pretty vivid dreams, but being an artist/writer/musician, it is kinda like a creativity enhancing drug. One last thing: IF Sustiva is what they gave you (probably other meds that penetrate as well by now), it *WILL* make you have a false-positive for THC in any drug test....it got me in trouble with the Veteran's Admin. initially because I was on pain management, and they only took 2 weeks to step me off pretty high dosage of Morphine, which instigated my now 4 months of diarrhea. I divorced the VA system after their incompetence, as I even brought the drug-data on Sustiva, mentioning therein. Thought I's let you know that in case you work where this may be an issue. Peace and be good to your brain! "
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Reply #3 - 09/17/09  8:08am
" Forgot to add that a more specific spectral test can be done to confirm the false-positive, if Sustiva is your new drug.
Peace "
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Reply #4 - 09/17/09  4:38pm
" Thanks for the input both. :)

N, I know what you mean about the wild dreams and Atripla. I was on that for around six weeks and felt like I was on a rollercoaster from the minute I closed my eyes at night till the next morning. Sometimes it was nice, other times a pain!

The drug my doctor wants to put me on is called Prezista (darunavir), to replace my Reyataz (atazanavir).

Thanks again both. Was really useful information. "
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Reply #5 - 09/19/09  10:27pm
" I am on atripla too and also have had crazy dreams.Everything from nightmares to just plain strange!The thing is that they are so real that when that alarm goes off in the morning it takes a while to get back to reality. "

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