What is Fructose-Intolerance
Fructose intolerance (Dietary Fructose Intolerance, or DFI) is a hereditary condition due to a deficiency of liver enzymes that metabolise fructose. The deficient enzyme is Fruc...
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Fructose intolerance (Dietary Fructose Intolerance, or DFI) is a hereditary condition due to a deficiency of liver enzymes that metabolise fructose. The deficient enzyme is Fruc...

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Fructose intolerance (Dietary Fructose Intolerance, or DFI) is a hereditary condition due to a deficiency of liver enzymes that metabolise fructose. The deficient enzyme is Fructose-1-phosphate aldolase, this means that the fructose cannot be further metabolised beyond fructose-1-phosphate. This traps phosphates; which are needed to phosphorolyse glycogen phosphorolase to carry on to make glucose. therefore glucose cannot be made through the breakdown of glycogen nor from gluconeogenesis, resulting in severe hypoglycaemia. If fructose is ingested, vomiting, hypoglycaemia and eventually kidney failure will follow.
Dietary Fructose Intolerance should not be confused with fructose malabsorption, a deficiency of fructose transporter enzyme in the enterocytes, which leads to abdominal bloating, diarrhea and/or constipation.




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