What is Depression
Clinical depression is a state of sadness or melancholia that has advanced to the point of being disruptive to an individual's social functioning and/or activities of daily living....
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Clinical depression is a state of sadness or melancholia that has advanced to the point of being disruptive to an individual's social functioning and/or activities of daily living....

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TCAs, SSRIs, and SNRIs Useless
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Hello and good day. I am a twenty year old student with ongoing and worsening depression. I have tried a number of different medications including but not limited to trazodone, prozac, lexapro, effexor and seroquel with no success. I recently have stopped using heroin which helped with my depression and pain for the past two years or so but now at the end of it, I am only worse off than before. Doctors have no idea why I could be "so depressed" especially since I am twenty years old and have normal blood work. I suffer from a number of conditions but pain and depression are my worst symptoms, with no relief from either, except when I take opiates. I burned my hand and was prescribed percocet and oxycodone instant 5mg about two months ago and during that time I was the happiest I have ever felt in years. While I was still using last semester I performed the best in college I have ever done in two years. Now, however, I cannot reasonably continue along that path for many reasons. I just cannot deal with this pain and depression anymore. The solution is so simple... but doctors keep saying that heroin use made me depressed but this is not the case. I just don not have any more patience to deal with this stigmatic culture. My pain is real and the only relief is from opiates. Constant pain equals constant suffering equals chronic depression. Its so simple... I am just ready, some days, to take the ultimate solution and cease all of my suffering. I need a doctor that is willing to help. Not stigmatize/marginalize.
Posted on 11/05/09, 04:11 pm |
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Wow. Sleep deprivation got the best of me with that last post. I did not mean to invalidate the study at all. I meant to say that some addicts, during their use, or people prone to addiction, need to feel high or want to.
Here are the links I have found useful and WILL bring to my docs attention! "Treatment Augmentation With Opiates in Severe and Refractory Major Depression " http://ajp.psychiatryonline.org/cg... "The Endomorphin System and Its Evolving Neurophysiological Role" http://pharmrev.aspetjournals.org/... "The Antidepressant -like Effects of Delta-Opioid Receptor Agonists" http://molinterv.aspetjournals.org... Remember, this is what I have found about what may be useful for me and not what someone else is going through. Cheers.
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