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CLINICAL TRIALS 
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Dementia Information

  • Dementia is the progressive decline in cognitive function due to damage or disease in the brain beyond what might be expected from normal aging. Particularly affected areas may be memory, attention, language and problem solving, although particularly in the later stages of the condition, affected persons may be disoriented in time (not knowing what day of the week, day of the month, what month or even what year it is), place (not knowing where they are) and person (not knowing who they are). Symptoms of dementia can be classified as either reversible or irreversible depending upon the etiology of the disease. Less than 10% of all dementias are reversible. Dementia is a non-specific term that encompasses many disease processes, just as fever is attributable to many etiologies...
  • Proper differential diagnosis between the types of dementia (see below) will require, at the least, referral to a specialist, e.g. a geriatric internist, geriatric psychiatrist, neurologist, neuropsychologist or geropsychologist. However, there are some brief (5-15 minutes) tests that have good reliability and can be used in the office or other setting to evaluate cognitive status. Examples of such tests include the abbreviated mental test score (AMTS) and the mini mental state examination (MMSE).

    An AMTS score of less than six and an MMSE score under 24 suggests a need for further evaluation. Of course, this must be interpreted in the context of the person's educational and other background, and particular circumstances. Routine blood tests are usually performed to rule out treatable causes. These tests include vitamin B12, folic acid, thyroid-stimulating hormone (TSH), C-reactive protein, full blood count, electrolytes, calcium, renal function and liver enzymes. Abnormalities may suggest vitamin deficiency, infection or other problems that commonly cause confusion or disorientation in the elderly. Chronic use of substances such as alcohol can also predispose the patient to cognitive changes suggestive of dementia.

    A CT scan or magnetic resonance imaging (MRI scan) is commonly performed. This may suggest normal pressure hydrocephalus, a potentially reversible cause of dementia, and can yield information relevant to other types of dementia, such as infarction (stroke) that would point at a vascular type of dementia. Sometimes neuropsychological testing is helpful as well.

    The final diagnosis of dementia is made on the basis of the clinical picture. For research purposes, the diagnosis depends on both a clinical diagnosis and a pathological diagnosis (ie, based on the examination of brain tissue, usually from autopsy).

  • Click to expand

Health Blogs

On Sharecare we’re serving up: tips in honor of Alzheimer’s Awareness Month, help for stiff joints in cold weather, and a quick way to lower your risk of heart disease.
  1. Don’t wait until New Years to pledge a healthier lifestyle – start now. ... Read More »
Despite the fact that millions of Americans suffer from Alzheimer’s disease, little is known about what causes affected individuals to descend into dementia. Two proteins called tau and beta amyloid were thought to be involved because they were found in widespread clumps and tangles in the brains of those with Alzheimer’s, but not in those ... Read More »
Physical exercise is like a natural wonder drug for your brain and body. It gets your heart to pump life-giving blood into your brain, supplying more oxygen, glucose and nutrients that your brain needs to function at its best. The benefits of exercise are tremendous:
- it encourages the growth of new brain cells - it enhances ... Read More »

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