What is COPD Emphysema

Chronic obstructive pulmonary disease (COPD) is an umbrella term for a group of respiratory tract diseases that are characterized by airflow obstruction or limitation. It is usuall...

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Discussion:
Spiriva + Advair improves quality of life
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A new study published in the Annals of Internal Medicine April 17th 2007 will make news Im sure

Here are the highlights:
1) Pts with COPD were treated with either
a) spiriva (tiotropium) alone
b) spiriva + a steroid (salmeterol)
c) spiriva + advair (which is a combo of a steroid and a long acting bronchodilator)

2) 449 patients with moderate or severe COPD were studied
3) Conclusions: the addition of ADVAIR to SPIRIVA did not influence rates of COPD exacerbation but DID improve lung function, quality of life, and hospitalization rates in patients with moderate to severe COPD

Have we found the magic combination? It would be nice to find one that improves mortality from COPD but at least this is a regimen that seems to improve quality of life!

Dr O.
Posted on 04/27/07, 10:04 pm
11 Replies | Most Recent Add Your Reply
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Reply #1 - 04/28/07  12:33am
" I take the combination of Spiriva and Advair, along with Xopenex and oxygen. I have severe COPD and these medicines enable me to get where I need to be most of the time. I'm still able to drive and that's a blessing. "
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Reply #2 - 04/29/07  10:32am
" I was taking Spiriva and an Albuterol Inhaler. Since my doctor started me on Advair 250/50 on December 14,2006 I no longer need the Albuterol Inhaler,but I always have it with me anyway. For me Advair has made a significant difference. "
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Reply #3 - 04/29/07  12:10pm
" Arlene:
The study was funded by a Grant from the Canadian Institutes of Health Research and the Ontario Thoracic Society (Dr Shawn Aaron is the principle author). THIS STUDY WAS NOT FUNDED BY THE PHARMACEUTICAL INDUSTRY. Im not sure if youd have access to the full text online but www.annals.org you can search it to find the abstract at least.
Hope this helps
Dr O. "
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Reply #4 - 05/04/07  11:22pm
" Thank you to sassyme for reminding me that i will MENTION anytime a published study is funded by the drug companies...as we should always think about that
Dr O. "
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Reply #5 - 05/07/07  11:29am
" I have tried Spiriva twice w/hardly any change. I have taken Albutueral (in the past-now xopenex), atrovent, and pulmicort inhalers for several years. I tried dropping the atrovent inhaler and replaced it w/Spiriva; but again I actually was sob each time. Is it because I am used to one regiment for so many years? I also use oxygen (8-l0LM) 24/7... "
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Reply #6 - 05/08/07  10:58pm
" how long do you give the meds to start working? i've been on spiriva for about 2 1/2 weeks and haven't noticed any difference. (i'm on oxygen, 24/7 at 2 liters and use abuterol as a rescue...alot). thanks. margaret "
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Reply #7 - 05/08/07  11:11pm
" MamaMarg:

I have noticed from other people on other groups that one has to give Spiriva a couple of months; depending on the individual.

I use my inhalers four times per day and have for a long,long time.

Am leary of people that claim the first week of taking Spiriva they stop taking their other inhalers and start running up hills; almost to the point of them saying ; no longer need oxygen. (and yet I have seen this on other sites). "
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Reply #8 - 05/10/07  1:42am
" thank you!!! that's reassuring to hear that i'm not totally crazy! i was beginning to wonder. so, you can use the rescue albuterol more than what it says? even the albuterol doesnt' make me feel much better. i'm just a total cry baby i think. but thanks for your info. margaret "
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Reply #9 - 05/15/07  7:00pm
" I was first put on albuterol and it worked for 4-6 hours, then they put me on Advair, 1 puff twice a day. It works pretty well I guess, but I'm also on oxygen especially at night. Doctor said I didn't generate enough oxygen on my own to sleep all night. "
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Reply #10 - 07/24/08  2:03am
" I was on albuterol and spiriva for a few months and wasn't doing well at all. They added advair to the mix and I felt like I got a new lease on life. I have severe COPD and my days are so up and down. I still do have to use the albuterol rescue inhaler daily. I'm trying to get over a cold maybe that's why. I am able to work a fulltime job @ 11 hrs a day 4 days a week and those medications are allowing that to happen. I don't require oxygen. "

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