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Antiphospholipid Syndrome Information
Antiphospholipid syndrome (or antiphospholipid antibody syndrome) is a disorder of coagulation which causes thrombosis in both arteries and veins, as well as recurrent miscarriage. It is due to the autoimmune production of antibodies against cell membrane constituents. It is occasionally referred to as Hughes' syndrome after the rheumatologist Dr Graham R.V. Hughes (St. Thomas' Hospital, London, UK).
A very rare form is the catastrophic antiphospholipid syndrome, in which there is rapid organ dysfunction and failure. It carries a high mortality.
Often, this disease is treated by giving aspirin to inhibit platelet activation, and/or warfarin as an anticoagulant. The goal of the prophylactic treatment is to maintain the patient's INR between 2.0-3.0. It is not usually done in patients who have not had any thrombotic symptoms. During pregnancy, heparin is used instead of warfarin because of warfarin's teratogenicity.
Women with recurrent miscarriage are often advised to take aspirin and to start heparin (or low molecular weight heparin) treatment after missing a period. This is the most effective treatment at the moment.
Health Blogs
Posted in
A new Down syndrome blood test has recently been released that will
allow parents to detect whether or not their baby will have Down
syndrome more safely in the pregnancy, without the risk of
miscarriage. Although its arrival should not come as much surprise,
a new Down syndrome blood test will certainly raise ethical
concerns surrounding the
... Read More »
What does it mean if you dream that you’re flying? Or being chased?
Or walking around naked? We have a great desire to make meaning out
of our dreams, and hundreds of dream dictionaries say they can
interpret symbols and imagery in our dreams. But can they really
explain them? Dreams and dream imagery are real in the sense that
they can have
... Read More »
As many on Dailystrength know, recent genetics discoveries are expanding basic science research into the basic mechanism of health and disease. Over the past decade, gene alterations conferring an increased risk for adult onset conditions such as cancer, diabetes, cardiovascular, and other common diseases have been identified. ... Read More »
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