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Alzheimer's Disease Information

  • Alzheimer's disease (AD), a neurodegenerative disease, is the most common cause of dementia and characterized clinically by progressive cognitive deterioration together with declining activities of daily living and neuropsychiatric symptoms or behavioral changes. The most striking early symptom is memory loss (amnesia), usually manifests as minor forgetfulness that becomes steadily more pronounced with illness progression, with relative preservation of older memories...
  • As the disorder progresses, cognitive (intellectual) impairment extends to the domains of language (aphasia), skilled movements (apraxia), recognition (agnosia) and those functions (such as decision-making and planning) closely related to the frontal and temporal lobes of the brain as they become disconnected from the limbic system, reflecting extension of the underlying pathological process. This consists principally of neuronal (cell) loss (or atrophy), together with an inflammatory response to the deposition of amyloid plaques and neurofibrillary tangles. Genetic factors are known to be important, and autosomal dominant mutations (variations) in three different genes - Presenilin 1, Presenilin 2, and Amyloid Precursor Protein - have been identified that account for a small number of cases of familial, early-onset AD. For late onset AD (LOAD), only one susceptibility gene has so far been identified - the epsilon 4 allele of the Apolipoprotein E gene. Age of onset itself has a heritability of around 50%.

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Health Blogs

Dementia has become one of the biggest diseases of old age in America. The number of people living and dying with dementia has been on the rise over the past decade and it’s estimated that five million older adults are currently living with Alzheimer’s, the most common form. In spite of the widespread presence of this illness, new ... Read More »
Researchers have been working for decades to unravel the secrets of Alzheimer’s disease, a type of dementia that seems to be linked to the buildup of certain proteins, called Aβ and tau, in the brain. Unfortunately, how and why those proteins build up is still a mystery. One group of researchers took a step forward in understanding why ... Read More »
While hunger might be the most obvious effect of dieting or fasting, dropping the amount you eat can have broader effects on your body than just feeling the need to eat more. Researchers had observed that fasting for long periods of time and exercising could both drop inflammation in a person’s body as measured by blood markers. While some ... Read More »

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Michael T Murray, ND
Naturopathic Medicine

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